Synthesis and properties of novel biomimetic and thermo-responsive dextran-based biohybrids
文献类型：期刊论文
| 作者 | Li, Fan1,2; Pei, Danfeng2; Huang, Qingrong3; Shi, Tongfei2; Zhang, Guo1 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2014-01-02 |
| 卷号 | 99页码:728-735 |
| 关键词 | Glycopolymer Dextran Atom Transfer Radical Polymerization Polysaccharide Biodegradable Nanoparticles |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2013.09.020 |
| 英文摘要 | A new class of biodegradable, biomimetic and thermo-responsive dextran/synthetic glycopolymer biohybrids (dextran-graft-poly(lactobionamidoethyl methacrylate)-block-poly(di(ethylene glycol) methyl ether methacrylate), dextran-g-(PLAMA-b-PDEGMA)), was synthesized by the direct atom transfer radical polymerization (ATRP) of unprotected lactobionamidoethyl methacrylate (LAMA) glycomonomer and di(ethylene glycol) methyl ether methacrylate (DEGMA) monomer. The dextran macroinitiator for ATRP was prepared by partial esterification of the hydroxyl groups of the polysaccharide with 2-bromo-2-methylpropionic acid (BrMPA). The biohybrids containing PDEGMA segments exhibited a lower critical solution temperature (LCST) behavior, which changed from unimers to aggregates in solutions. Moreover, it was demonstrated that these biohybrids had specific biomolecular recognition with ricinus communis agglutinin 120 (RCA(120)) in comparison with bovine serum albumin (BSA). Furthermore, these biohybrids showed good biocompatibility in the cytotoxicity assays. This hopefully provides a platform for targeted drug delivery and studying the biomolecular recognition between sugar and lectin. (C) 2013 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000329256600092 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/52465]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, Guo |
| 作者单位 | 1.Jilin Univ, Inst Mat Sci & Engn, Changchun 130023, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.Rutgers State Univ, Cook Coll, Dept Food Sci, New Brunswick, NJ 08901 USA |
| 推荐引用方式 GB/T 7714 | Li, Fan,Pei, Danfeng,Huang, Qingrong,et al. Synthesis and properties of novel biomimetic and thermo-responsive dextran-based biohybrids[J]. CARBOHYDRATE POLYMERS,2014,99:728-735. |
| APA | Li, Fan,Pei, Danfeng,Huang, Qingrong,Shi, Tongfei,&Zhang, Guo.(2014).Synthesis and properties of novel biomimetic and thermo-responsive dextran-based biohybrids.CARBOHYDRATE POLYMERS,99,728-735. |
| MLA | Li, Fan,et al."Synthesis and properties of novel biomimetic and thermo-responsive dextran-based biohybrids".CARBOHYDRATE POLYMERS 99(2014):728-735. |
入库方式： OAI收割
来源：化学研究所
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