A Light-Responsive Release Platform by Controlling the Wetting Behavior of Hydrophobic Surface
文献类型：期刊论文
| 作者 | Chen, Linfeng1,2; Wang, Wenqian3; Su, Bin1; Wen, Yongqiang3; Li, Chuanbao3; Zhou, Yabin3; Li, Mingzhu1; Shi, Xiaodi1,2; Du, Hongwu3; Song, Yanlin1 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2014 |
| 卷号 | 8期号:1页码:744-751 |
| 关键词 | Mesoporous Silica Spiropyran Light-responsive Controlled Release Wetting |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/nn405398d |
| 英文摘要 | Controlled release system based on mesoporous silica (MS) nanomaterials has drawn great attention over the past decades due to its potential biomedical applications. Herein, a light responsive release system based on MS nanoparticles was achieved by adjusting the wetting of the MS surface. At the starting stage, the surface of MS modified with optimal ratio of spiropyran to fluorinated silane (MS-FSP) was protected from being wetted by water, successfully inhibiting the release of model cargo molecules, fluorescein disodium (FD). Upon irradiation with 365 nm UV light, the conformational conversion of spiropyran from a "closed" state to an "open" state caused the surface to be wetted, leading to the release of FD from the pores. The further in vitro studies demonstrated the system loaded with anticancer drug camptothecin (CPT) could be effectively controlled to release the drug by UV light stimuli to enhance cytotoxicity for EA.hy926 cells and He La cells. This wettability-determined smart release platform could be triggered by remote stimuli, which might hold promise in the applications of drug delivery and cancer therapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000330542900076 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/52497]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wen, Yongqiang |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Green Printing, Key Lab Organ Solids, BNLMS,Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Sci & Technol Beijing, Res Ctr Bioengn & Sensing Technol, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Linfeng,Wang, Wenqian,Su, Bin,et al. A Light-Responsive Release Platform by Controlling the Wetting Behavior of Hydrophobic Surface[J]. ACS NANO,2014,8(1):744-751. |
| APA | Chen, Linfeng.,Wang, Wenqian.,Su, Bin.,Wen, Yongqiang.,Li, Chuanbao.,...&Jiang, Lei.(2014).A Light-Responsive Release Platform by Controlling the Wetting Behavior of Hydrophobic Surface.ACS NANO,8(1),744-751. |
| MLA | Chen, Linfeng,et al."A Light-Responsive Release Platform by Controlling the Wetting Behavior of Hydrophobic Surface".ACS NANO 8.1(2014):744-751. |
入库方式： OAI收割
来源：化学研究所
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