Merging Aerobic Oxidation and Enamine Catalysis in the Asymmetric alpha-Amination of beta-Ketocarbonyls Using N-Hydroxycarbamates as Nitrogen Sources
文献类型：期刊论文
| 作者 | Xu, Changming1,2; Zhang, Long1,2; Luo, Sanzhong1,2 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2014-04-14 |
| 卷号 | 53期号:16页码:4149-4153 |
| 关键词 | Aerobic Oxidation Alpha-amination Beta-ketocarbonyls Enamine Catalysis Organocatalysis |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201400776 |
| 英文摘要 | We describe herein an unprecedented asymmetric alpha-amination of beta-ketocarbonyls under aerobic conditions. The process is enabled by a simple chiral primary amine through the coupling of a catalytic enamine ester intermediate and a nitrosocarbonyl (generated in situ) derived from N-hydroxycarbamate. The reaction features high chemoselectivity and excellent enantioselectivity for a broad range of substrates. |
| 语种 | 英语 |
| WOS记录号 | WOS:000338968700013 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/52793]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Luo, Sanzhong |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, BNLMS, Beijing 100190, Peoples R China 2.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Changming,Zhang, Long,Luo, Sanzhong. Merging Aerobic Oxidation and Enamine Catalysis in the Asymmetric alpha-Amination of beta-Ketocarbonyls Using N-Hydroxycarbamates as Nitrogen Sources[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(16):4149-4153. |
| APA | Xu, Changming,Zhang, Long,&Luo, Sanzhong.(2014).Merging Aerobic Oxidation and Enamine Catalysis in the Asymmetric alpha-Amination of beta-Ketocarbonyls Using N-Hydroxycarbamates as Nitrogen Sources.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,53(16),4149-4153. |
| MLA | Xu, Changming,et al."Merging Aerobic Oxidation and Enamine Catalysis in the Asymmetric alpha-Amination of beta-Ketocarbonyls Using N-Hydroxycarbamates as Nitrogen Sources".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53.16(2014):4149-4153. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。