Fibril Aggregates Formed by a Glatiramer-Mimicking Random Copolymer of Amino Acids
文献类型：期刊论文
| 作者 | Lai, Jingjing1; Fu, Wenxin2; Zhu, Lin3; Guo, Ruohai1; Liang, Dehai3; Li, Zhibo2; Huang, Yanbin1 |
| 刊名 | LANGMUIR
 |
| 出版日期 | 2014-06-24 |
| 卷号 | 30期号:24页码:7221-7226 |
| ISSN号 | 0743-7463 |
| DOI | 10.1021/la501622t |
| 英文摘要 | Amyloid formation is now considered a universal and intrinsic property of all proteins, irrespective of their sequences. Therefore, it is interesting to see whether random copolymers of amino acids can also form amyloid aggregates. Here we use a copolymer of 4 amino acids, mimicking the clinically used drug Glatiramer, and demonstrate that it does form amyloid-like fibrils in the aqueous solution despite its random sequence structure. The fibrillar aggregates show an alanine-rich beta-sheet secondary structure, proving the high tolerance of amyloid aggregates to the sequence irregularity in poly(amino acid)s, and suggesting the potential application of random copolymers as amyloid materials. |
| 语种 | 英语 |
| WOS记录号 | WOS:000338089600024 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/52867]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liang, Dehai |
| 作者单位 | 1.Tsinghua Univ, Dept Chem Engn, Key Lab Adv Mat MOE, Beijing 100084, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 3.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lai, Jingjing,Fu, Wenxin,Zhu, Lin,et al. Fibril Aggregates Formed by a Glatiramer-Mimicking Random Copolymer of Amino Acids[J]. LANGMUIR,2014,30(24):7221-7226. |
| APA | Lai, Jingjing.,Fu, Wenxin.,Zhu, Lin.,Guo, Ruohai.,Liang, Dehai.,...&Huang, Yanbin.(2014).Fibril Aggregates Formed by a Glatiramer-Mimicking Random Copolymer of Amino Acids.LANGMUIR,30(24),7221-7226. |
| MLA | Lai, Jingjing,et al."Fibril Aggregates Formed by a Glatiramer-Mimicking Random Copolymer of Amino Acids".LANGMUIR 30.24(2014):7221-7226. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。