beta-conjugation of gadolinium(III) DOTA complexes to zinc(II) porpholactol as potential multimodal imaging contrast agents
文献类型：期刊论文
| 作者 | Ke, Xian-Sheng; Tang, Juan; Yang, Zi-Shu; Zhang, Jun-Long |
| 刊名 | JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
 |
| 出版日期 | 2014-10-01 |
| 卷号 | 18期号:10-11页码:950-959 |
| 关键词 | Porphyrinoid Beta-conjugation Gadolinium Multimodal Imaging Photodynamic Therapy |
| ISSN号 | 1088-4246 |
| DOI | 10.1142/S1088424614500758 |
| 英文摘要 | Synthesis of two bimodal imaging agents consist of a hydrophobic zinc(II) tetrapentafluorophenylporpholactol core and a beta-substituted hydrophilic Gd(III) DO3A (ZnLGd539) or DOTA (ZnLGd595) like moiety has been described (DO3A = 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid, DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). Through beta-conjugation approach, the absorption at deep red region increases compared to traditional conjugation methods at meso-position. More importantly, these new complexes possess largely improved ionic relaxitivites relative to the sole Gd(III) magnetic resonance imaging (MRI) agents such as Gd(III) DO3A and Gd(III) DOTA like complexes. Combining the optical and magnetic resonance measurements in aqueous media, the largely enhanced r(1) relaxivities was attributed to the aggregation of ZnLGd539 and ZnLGd595 in aqueous media. Furthermore, fluorescence and magnetic resonance imaging experiment showed that both ZnLGd539 and ZnLGd595 can be applied as potential bimodal imaging contrast agents. Finally, both compounds showed no dark cytotoxicity and good photocytotoxicity (IC50 = 1.73 +/- 0.13 and 1.52 +/- 0.10 mu M for ZnLGd539 and ZnLGd595 respectively) on Hela cells. |
| 语种 | 英语 |
| WOS记录号 | WOS:000346189500014 |
| 出版者 | WORLD SCI PUBL CO INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/52879]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, Jun-Long |
| 作者单位 | Peking Univ, Coll Chem & Mol Engn, State Key Lab Rare Earth Mat Chem & Applicat, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ke, Xian-Sheng,Tang, Juan,Yang, Zi-Shu,et al. beta-conjugation of gadolinium(III) DOTA complexes to zinc(II) porpholactol as potential multimodal imaging contrast agents[J]. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES,2014,18(10-11):950-959. |
| APA | Ke, Xian-Sheng,Tang, Juan,Yang, Zi-Shu,&Zhang, Jun-Long.(2014).beta-conjugation of gadolinium(III) DOTA complexes to zinc(II) porpholactol as potential multimodal imaging contrast agents.JOURNAL OF PORPHYRINS AND PHTHALOCYANINES,18(10-11),950-959. |
| MLA | Ke, Xian-Sheng,et al."beta-conjugation of gadolinium(III) DOTA complexes to zinc(II) porpholactol as potential multimodal imaging contrast agents".JOURNAL OF PORPHYRINS AND PHTHALOCYANINES 18.10-11(2014):950-959. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。