One-Step Preparation of a Water-Soluble Carbon Nanohorn/Phthalocyanine Hybrid for Dual-Modality Photothermal and Photodynamic Therapy
文献类型：期刊论文
| 作者 | Jiang, Bang-Ping1; Hu, Lan-Fang1; Shen, Xing-Can1; Ji, Shi-Chen1; Shi, Zujin2; Liu, Chan-Juan1,3; Zhang, Li1; Liang, Hong1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2014-10-22 |
| 卷号 | 6期号:20页码:18008-18017 |
| 关键词 | Single-walled Carbon Nanohorns Metal Phthalocyanine Photothermal Therapy Photodynamic Therapy |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/am504860c |
| 英文摘要 | The biomedical applications of carbon nanomaterials, especially integrating noninvasive photothermal therapy (PTT) and photodynamic therapy (PDT), into a single system have enormous potential in cancer therapy. Herein, we present a novel and facile one-step method for the preparation of water-soluble single-walled carbon nanohorns (SWNHs) and metal phthalocyanines (MPc) hybrid for PTT and PDT. The hydrophilic MPc, tetrasulfonic acid tetrasodium salt copper phthalocyanine (TSCuPc), is coated on the surface of SWNHs via noncovalent pi-pi interaction using the sonication method. In this PTT/PDT nanosystem, SWNHs acts as a photosensitizer carrier and PTT agent, while TSCuPc acts as a hydrophilic and PDT agent. The EPR results demonstrated that the generated reactive oxygen species (ROS) not only from the photoinduced electron transfer process from TSCuPc to SWNHs but also from SWNHs without exciting TSCuPc to its excited state. The test of photothermal conversion proved that not only do SWNHs contribute to the photothermal therapy (PTT) effect, TSCuPc probably also contributes to that when it coats on the surface of SWNHs upon exposure to a 650-nm laser. More importantly, the results of in vitro cell viability revealed a significantly enhanced anticancer efficacy of combined noninvasive PTT/PDT, indicating that the SWNHs-TSCuPc nanohybrid is a hopeful candidate material for developing an efficient and biocompatible nanoplatform for biomedical application. |
| 语种 | 英语 |
| WOS记录号 | WOS:000343684200080 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/52899]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Shen, Xing-Can |
| 作者单位 | 1.Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, Key Lab Chem & Mol Engn Med Resources, Minist Educ, Guilin 541004, Peoples R China 2.Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 3.Guilin Univ Technol, Sch Mat Sci & Engn, Key Lab New Proc Technol Nonferrous Met & Mat, Minist Educ, Guilin 541004, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Bang-Ping,Hu, Lan-Fang,Shen, Xing-Can,et al. One-Step Preparation of a Water-Soluble Carbon Nanohorn/Phthalocyanine Hybrid for Dual-Modality Photothermal and Photodynamic Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6(20):18008-18017. |
| APA | Jiang, Bang-Ping.,Hu, Lan-Fang.,Shen, Xing-Can.,Ji, Shi-Chen.,Shi, Zujin.,...&Liang, Hong.(2014).One-Step Preparation of a Water-Soluble Carbon Nanohorn/Phthalocyanine Hybrid for Dual-Modality Photothermal and Photodynamic Therapy.ACS APPLIED MATERIALS & INTERFACES,6(20),18008-18017. |
| MLA | Jiang, Bang-Ping,et al."One-Step Preparation of a Water-Soluble Carbon Nanohorn/Phthalocyanine Hybrid for Dual-Modality Photothermal and Photodynamic Therapy".ACS APPLIED MATERIALS & INTERFACES 6.20(2014):18008-18017. |
入库方式： OAI收割
来源：化学研究所
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