A Cresyl Violet-Based Fluorescent Off-On Probe for the Detection and Imaging of Hypoxia and Nitroreductase in Living Organisms
文献类型：期刊论文
| 作者 | Wan, Qiong-Qiong; Gao, Xing-Hui; He, Xin-Yuan; Chen, Su-Ming; Song, Yan-Chao; Gong, Qiu-Yu; Li, Xiao-Hua; Ma, Hui-Min |
| 刊名 | CHEMISTRY-AN ASIAN JOURNAL
 |
| 出版日期 | 2014-08-01 |
| 卷号 | 9期号:8页码:2058-2062 |
| 关键词 | Amines Fluorescence Imaging Fluorescent Probe Hypoxic Tumor Cells Reduction |
| ISSN号 | 1861-4728 |
| DOI | 10.1002/asia.201402364 |
| 英文摘要 | A new cresyl violet-based fluorescent off-on probe has been developed through a one-step synthesis for the detection of nitroreductase (NTR) and hypoxia. The detection mechanism is based on the NTR-catalyzed reduction of the probe to cresyl violet, accompanied with a large fluorescence enhancement at a long wavelength of 625 nm. The probe can detect NTR in aqueous solution with high selectivity and sensitivity, and the detection limit is 1 ngmL(-1) NTR. Most importantly, the probe has been successfully used to image not only NTR and hypoxia in living cells, but also the distribution of NTR in zebrafish in vivo. |
| 语种 | 英语 |
| WOS记录号 | WOS:000342675900010 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/52957]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Ma, Hui-Min |
| 作者单位 | Chinese Acad Sci, Key Lab Analyt Chem Living Biosyst, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, Qiong-Qiong,Gao, Xing-Hui,He, Xin-Yuan,et al. A Cresyl Violet-Based Fluorescent Off-On Probe for the Detection and Imaging of Hypoxia and Nitroreductase in Living Organisms[J]. CHEMISTRY-AN ASIAN JOURNAL,2014,9(8):2058-2062. |
| APA | Wan, Qiong-Qiong.,Gao, Xing-Hui.,He, Xin-Yuan.,Chen, Su-Ming.,Song, Yan-Chao.,...&Ma, Hui-Min.(2014).A Cresyl Violet-Based Fluorescent Off-On Probe for the Detection and Imaging of Hypoxia and Nitroreductase in Living Organisms.CHEMISTRY-AN ASIAN JOURNAL,9(8),2058-2062. |
| MLA | Wan, Qiong-Qiong,et al."A Cresyl Violet-Based Fluorescent Off-On Probe for the Detection and Imaging of Hypoxia and Nitroreductase in Living Organisms".CHEMISTRY-AN ASIAN JOURNAL 9.8(2014):2058-2062. |
入库方式： OAI收割
来源：化学研究所
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