Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery. of doxorubicin
文献类型：期刊论文
| 作者 | Li, Mingqiang1,5; Tang, Zhaohui1; Lv, Shixian1,5; Song, Wantong1; Hong, Hua4; Jing, Xiabin3; Zhang, Yuanyuan2; Chen, Xuesi1 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2014-04-01 |
| 卷号 | 35期号:12页码:3851-3864 |
| 关键词 | Drug Delivery Chemotherapy Crosslinking Nanoparticle Polysaccharide Controlled Drug Release |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2014.01.018 |
| 英文摘要 | pH responsive cisplatin prodrug crosslinked polysaccharide-based nanoparticles were developed from succinic acid decorated dextran (Dex-SA) for active loading and triggered intracellular release of doxorubicin (DOX). Nanoparticles with uniform size were formed spontaneously in aqueous medium via electrostatic interaction between anionic Dex-SA and cationic DOX, and subsequently transformed into crosslinked nanoparticles (CL-Nanoparticles) in situ by readily crosslinking the micelles via chelate interactions between the ionic polymeric carrier and the platinum (II) antitumor drug. This strategy eliminated the need of organic solvents and sophisticated processes in the drug loading procedure. The in vitro release studies showed that DOX was released from the CL-Nanoparticles in a controlled and pH dependent manner. Furthermore, the pharmacokinetics and biodistribution investigations indicated that, as compared to the non-crosslinked nanoparticles (NCL-Nanoparticles) and free DOX, the CLNanoparticles significantly prolonged the blood circulation time of drug, decreased accumulation in the normal tissues and enriched drug into the tumors. As a consequence, the DOX-loaded CL-Nanoparticles exhibited enhanced therapeutic efficacy in tumor-bearing mice compared with the NCL-Nanoparticles and free DOX, which were further confirmed by the histological and immunohistochemical analyses. These cisplatin prodrug crosslinked polysaccharide nanoparticles proved to be a promising nanomedicine drug delivery system for tumor-targeted delivery of DOX. (c) 2014 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000332431700014 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53121]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Xuesi |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China 2.Wake Forest Sch Med, Wake Forest Inst Regenerat Med, Winston Salem, NC 27157 USA 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 4.Jilin Univ, Lab Anim Ctr, Changchun 130012, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Mingqiang,Tang, Zhaohui,Lv, Shixian,et al. Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery. of doxorubicin[J]. BIOMATERIALS,2014,35(12):3851-3864. |
| APA | Li, Mingqiang.,Tang, Zhaohui.,Lv, Shixian.,Song, Wantong.,Hong, Hua.,...&Chen, Xuesi.(2014).Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery. of doxorubicin.BIOMATERIALS,35(12),3851-3864. |
| MLA | Li, Mingqiang,et al."Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery. of doxorubicin".BIOMATERIALS 35.12(2014):3851-3864. |
入库方式： OAI收割
来源：化学研究所
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