Oxidation-Responsive OEGylated Poly-L-cysteine and Solution Properties Studies
文献类型：期刊论文
| 作者 | Fu, Xiaohui; Ma, Yinan; Shen, Yong; Fu, Wenxin; Li, Zhibo |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2014-03-01 |
| 卷号 | 15期号:3页码:1055-1061 |
| ISSN号 | 1525-7797 |
| DOI | 10.1021/bm5000554 |
| 英文摘要 | The oxidation-responsive behaviors of OEGylated poly-L-cysteine homopolypeptides, that is, poly(L-EG(x)MA-C)(n), were investigated. These poly-L-cysteine derivatives adopted mixed conformation in water, in which the beta-sheet accounted for a significant proportion. Upon oxidation, the thioethers in polypeptide side chains were converted to polar sulfone groups, which triggered the secondary structure transition from beta-sheet preferred conformation to random coil. Accordingly, the increase of side-chain polarity together with conformation changes increased samples' water solubility and cloud point temperature. Using mPEG(45)-NH2 as macroinitiator, we synthesized PEG(45)-b-poly(L-EG(2)MA-C)(22) diblock copolymer via ring-opening polymerization (ROP) of L-EG(2)MA-C N-carboxyanhydride (NCA). The PEG(45)-b-poly(L-EG(2)MA-C)(22) was able to self-assemble into spherical micelles in aqueous solution, and the micelles could undergo an oxidation-triggered disassembly due to the oxidation-responsive thioethers. Such a new class of oxidation-responsive polypeptides might provide a promising platform to construct inflammation targeting drug delivery systems. |
| 语种 | 英语 |
| WOS记录号 | WOS:000332756600040 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53181]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Zhibo |
| 作者单位 | Chinese Acad Sci, Inst Chem, BNLMS, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Xiaohui,Ma, Yinan,Shen, Yong,et al. Oxidation-Responsive OEGylated Poly-L-cysteine and Solution Properties Studies[J]. BIOMACROMOLECULES,2014,15(3):1055-1061. |
| APA | Fu, Xiaohui,Ma, Yinan,Shen, Yong,Fu, Wenxin,&Li, Zhibo.(2014).Oxidation-Responsive OEGylated Poly-L-cysteine and Solution Properties Studies.BIOMACROMOLECULES,15(3),1055-1061. |
| MLA | Fu, Xiaohui,et al."Oxidation-Responsive OEGylated Poly-L-cysteine and Solution Properties Studies".BIOMACROMOLECULES 15.3(2014):1055-1061. |
入库方式： OAI收割
来源：化学研究所
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