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Mass spectrometry imaging reveals the sub-organ distribution of carbon nanomaterials

文献类型：期刊论文

作者Chen, Suming1; Xiong, Caiqiao1; Liu, Huihui1; Wan, Qiongqiong1; Hou, Jian1; He, Qing1; Badu-Tawiah, Abraham2; Nie, Zongxiu1
刊名NATURE NANOTECHNOLOGY
出版日期2015-02-01
卷号10期号:2页码:176-182
ISSN号1748-3387
DOI10.1038/NNANO.2014.282
英文摘要Label and label-free methods to image carbon-based nanomaterials exist. However, label-based approaches are limited by the risk of tag detachment over time, and label-free spectroscopic methods have slow imaging speeds, weak photoluminescence signals and strong backgrounds. Here, we present a label-free mass spectrometry imaging method to detect carbon nanotubes, graphene oxide and carbon nanodots in mice. The large molecular weights of nanoparticles are difficult to detect using conventional mass spectrometers, but our method overcomes this problem by using the intrinsic carbon cluster fingerprint signal of the nanomaterials. We mapped and quantified the sub-organ distribution of the nanomaterials in mice. Our results showed that most carbon nanotubes and nanodots were found in the outer parenchyma of the kidney, and all three materials were seen in the red pulp of the spleen. The highest concentrations of nanotubes in the spleen were found within the marginal zone.
语种英语
WOS记录号WOS:000349468200020
出版者NATURE PUBLISHING GROUP
源URL[http://ir.iccas.ac.cn/handle/121111/53297]  
专题中国科学院化学研究所
通讯作者Nie, Zongxiu
作者单位1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA
推荐引用方式
GB/T 7714		 Chen, Suming,Xiong, Caiqiao,Liu, Huihui,et al. Mass spectrometry imaging reveals the sub-organ distribution of carbon nanomaterials[J]. NATURE NANOTECHNOLOGY,2015,10(2):176-182.
APA Chen, Suming.,Xiong, Caiqiao.,Liu, Huihui.,Wan, Qiongqiong.,Hou, Jian.,...&Nie, Zongxiu.(2015).Mass spectrometry imaging reveals the sub-organ distribution of carbon nanomaterials.NATURE NANOTECHNOLOGY,10(2),176-182.
MLA Chen, Suming,et al."Mass spectrometry imaging reveals the sub-organ distribution of carbon nanomaterials".NATURE NANOTECHNOLOGY 10.2(2015):176-182.

入库方式： OAI收割

来源：化学研究所

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