Bacterial chemoreceptors and chemoeffectors
文献类型：期刊论文
| 作者 | Bi, Shuangyu1,4; Lai, Luhua1,2,3 |
| 刊名 | CELLULAR AND MOLECULAR LIFE SCIENCES
 |
| 出版日期 | 2015-02-01 |
| 卷号 | 72期号:4页码:691-708 |
| 关键词 | Chemotactic Response Receptor Ligand Molecular Mechanism Receptor Design |
| ISSN号 | 1420-682X |
| DOI | 10.1007/s00018-014-1770-5 |
| 英文摘要 | Bacteria use chemotaxis signaling pathways to sense environmental changes. Escherichia coli chemotaxis system represents an ideal model that illustrates fundamental principles of biological signaling processes. Chemoreceptors are crucial signaling proteins that mediate taxis toward a wide range of chemoeffectors. Recently, in deep study of the biochemical and structural features of chemoreceptors, the organization of higher-order clusters in native cells, and the signal transduction mechanisms related to the on-off signal output provides us with general insights to understand how chemotaxis performs high sensitivity, precise adaptation, signal amplification, and wide dynamic range. Along with the increasing knowledge, bacterial chemoreceptors can be engineered to sense novel chemoeffectors, which has extensive applications in therapeutics and industry. Here we mainly review recent advances in the E. coli chemotaxis system involving structure and organization of chemoreceptors, discovery, design, and characterization of chemoeffectors, and signal recognition and transduction mechanisms. Possible strategies for changing the specificity of bacterial chemoreceptors to sense novel chemoeffectors are also discussed. |
| 语种 | 英语 |
| WOS记录号 | WOS:000348918500004 |
| 出版者 | SPRINGER BASEL AG |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53423]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Lai, Luhua |
| 作者单位 | 1.Peking Univ, Ctr Quantitat Biol, Beijing 100871, Peoples R China 2.Peking Univ, BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China 3.Peking Univ, Peking Tsinghua Ctr Life Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 4.Max Planck Inst Terr Microbiol, D-35043 Marburg, Germany |
| 推荐引用方式 GB/T 7714 | Bi, Shuangyu,Lai, Luhua. Bacterial chemoreceptors and chemoeffectors[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2015,72(4):691-708. |
| APA | Bi, Shuangyu,&Lai, Luhua.(2015).Bacterial chemoreceptors and chemoeffectors.CELLULAR AND MOLECULAR LIFE SCIENCES,72(4),691-708. |
| MLA | Bi, Shuangyu,et al."Bacterial chemoreceptors and chemoeffectors".CELLULAR AND MOLECULAR LIFE SCIENCES 72.4(2015):691-708. |
入库方式： OAI收割
来源：化学研究所
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