Binary release of ascorbic acid and lecithin from core-shell nanofibers on blood-contacting surface for reducing long-term hemolysis of erythrocyte
文献类型：期刊论文
| 作者 | Shi, Qiang1; Fan, Qunfu2,3; Ye, Wei1; Hou, Jianwen1; Wong, Shing-Chung4; Xu, Xiaodong2,3; Yin, Jinghua1 |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2015 |
| 卷号 | 125页码:28-33 |
| 关键词 | Anti-hemolysis Core-shell Nanofiber Ascorbic Acid Sebs Erythrocyte |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2014.11.013 |
| 英文摘要 | There is an urgent need to develop blood-contacting biomaterials with long-term anti-hemolytic capability. To obtain such biomaterials, we coaxially electrospin [ascorbic acid (AA) and lecithin]/poly (ethylene oxide) (PEO) core-shell nanofibers onto the surface of styrene-b-(ethylene-co-butylene)-b-styrene elastomer (SEBS) that has been grafted with poly (ethylene glycol) (PEG) chains. Our strategy is based on that the grafted layers of PEG render the surface hydrophilic to reduce the mechanical injure to red blood cells (RBCs) while the AA and lecithin released from nanofibers on blood-contacting surface can actively interact with RBCs to decrease the oxidative damage to RBCs. We demonstrate that (AA and lecithin)/PEO core-shell structured nanofibers have been fabricated on the PEG grafted surface. The binary release of AA and lecithin in the distilled water is in a controlled manner and lasts for almost 5 days; during RBCs preservation, AA acts as an antioxidant and lecithin as a lipid supplier to the membrane of erythrocytes, resulting in low mechanical fragility and hemolysis of RBCs, as well as high deformability of stored RBCs. Our work thus makes a new approach to fabricate blood-contacting biomaterials with the capability of long-term anti-hemolysis. (C) 2014 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000348951400004 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53443]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Shi, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Harbin Engn Univ, Coll Mat Sci & Chem Engn, Minist Educ, Polymer Mat Res Ctr, Harbin 150001, Peoples R China 3.Harbin Engn Univ, Coll Mat Sci & Chem Engn, Minist Educ, Key Lab Superlight Mat & Surface Technol, Harbin 150001, Peoples R China 4.Univ Akron, Dept Mech Engn, Akron, OH 44325 USA |
| 推荐引用方式 GB/T 7714 | Shi, Qiang,Fan, Qunfu,Ye, Wei,et al. Binary release of ascorbic acid and lecithin from core-shell nanofibers on blood-contacting surface for reducing long-term hemolysis of erythrocyte[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2015,125:28-33. |
| APA | Shi, Qiang.,Fan, Qunfu.,Ye, Wei.,Hou, Jianwen.,Wong, Shing-Chung.,...&Yin, Jinghua.(2015).Binary release of ascorbic acid and lecithin from core-shell nanofibers on blood-contacting surface for reducing long-term hemolysis of erythrocyte.COLLOIDS AND SURFACES B-BIOINTERFACES,125,28-33. |
| MLA | Shi, Qiang,et al."Binary release of ascorbic acid and lecithin from core-shell nanofibers on blood-contacting surface for reducing long-term hemolysis of erythrocyte".COLLOIDS AND SURFACES B-BIOINTERFACES 125(2015):28-33. |
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来源：化学研究所
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