Chirality-Assisted Ring-Like Aggregation of A beta(1-40) at Liquid-Solid Interfaces: A Stereoselective Two-Step Assembly Process
文献类型：期刊论文
| 作者 | Gao, Guanbin1; Zhang, Mingxi1; Lu, Pei3; Guo, Guanlun4; Wang, Dong3; Sun, Taolei1,2 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2015-02-09 |
| 卷号 | 54期号:7页码:2245-2250 |
| 关键词 | Amyloids Chirality Stereoselectivity Surface Assembly Surface Interactions |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201410768 |
| 英文摘要 | Molecular chirality is introduced at liquid-solid interfaces. A ring-like aggregation of amyloid A beta(1-40) on N-isobutyryl-L-cysteine (L-NIBC)-modified gold substrate occurs at low A beta(1-40) concentration, while D-NIBC modification only results in rod-like aggregation. Utilizing atomic force microscope controlled tip-enhanced Raman scattering, we directly observe the secondary structure information for A beta(1-40) assembly in situ at the nanoscale. D- or L-NIBC on the surface can guide parallel or nonparallel alignment of beta-hairpins through a two-step process based on electrostatic-interaction-enhanced adsorption and subsequent stereoselective recognition. Possible electrostatic interaction sites (R5 and K16) and a chiral recognition site (H14) of A beta(1-40) are proposed, which may provide insight into the understanding of this effect. |
| 语种 | 英语 |
| WOS记录号 | WOS:000349391000043 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53449]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Sun, Taolei |
| 作者单位 | 1.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China 2.Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China 3.Chinese Acad Sci, Inst Chem, BNLMS, Beijing 100190, Peoples R China 4.Wuhan Univ Technol, Hubei Key Lab Adv Technol Automot Components, Wuhan 430070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Guanbin,Zhang, Mingxi,Lu, Pei,et al. Chirality-Assisted Ring-Like Aggregation of A beta(1-40) at Liquid-Solid Interfaces: A Stereoselective Two-Step Assembly Process[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(7):2245-2250. |
| APA | Gao, Guanbin,Zhang, Mingxi,Lu, Pei,Guo, Guanlun,Wang, Dong,&Sun, Taolei.(2015).Chirality-Assisted Ring-Like Aggregation of A beta(1-40) at Liquid-Solid Interfaces: A Stereoselective Two-Step Assembly Process.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(7),2245-2250. |
| MLA | Gao, Guanbin,et al."Chirality-Assisted Ring-Like Aggregation of A beta(1-40) at Liquid-Solid Interfaces: A Stereoselective Two-Step Assembly Process".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.7(2015):2245-2250. |
入库方式： OAI收割
来源：化学研究所
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