Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles
文献类型：期刊论文
| 作者 | Xu, Yingying1; Tang, Huan1; Wang, Haifang2; Liu, Yuanfang1,2 |
| 刊名 | NANOMEDICINE
 |
| 出版日期 | 2015 |
| 卷号 | 10期号:3页码:419-431 |
| 关键词 | Gastrointestinal Tract Oral Tolerance Ovalbumin Silver Nanoparticles |
| ISSN号 | 1743-5889 |
| DOI | 10.2217/nnm.14.111 |
| 英文摘要 | Aim: The authors investigated the effect of silver nanoparticles (Ag NPs) on oral tolerance to dietary antigen ovalbumin (OVA) in mice. Materials & methods: Ag NPs were orally administered for 7 days before feeding of OVA and the immunological responses were assayed. Results: Polyvinyl pyrrolidone-coated Ag NPs (Ag NPs-PVP) were found to block the induction of oral tolerance to OVA. The physicochemical properties of the three kinds of Ag NPs were assessed and silver ions were found to inhibit the induction of oral tolerance, which might be the dominating factor in the blockade of oral tolerance by Ag NPs-PVP. Conclusion: Ag NPs with certain physicochemical properties can block oral tolerance to dietary antigen that may induce food allergy in humans. |
| 语种 | 英语 |
| WOS记录号 | WOS:000350246600008 |
| 出版者 | FUTURE MEDICINE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53471]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Haifang |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Yingying,Tang, Huan,Wang, Haifang,et al. Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles[J]. NANOMEDICINE,2015,10(3):419-431. |
| APA | Xu, Yingying,Tang, Huan,Wang, Haifang,&Liu, Yuanfang.(2015).Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles.NANOMEDICINE,10(3),419-431. |
| MLA | Xu, Yingying,et al."Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles".NANOMEDICINE 10.3(2015):419-431. |
入库方式： OAI收割
来源：化学研究所
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