Targeting of parallel c-myc G-quadruplex by dimeric cyanine dye supramolecular assembly: dependence on the linker length
文献类型：期刊论文
| 作者 | Yu, Lijia1,2; Yang, Qianfan1; Xiang, Junfeng1; Sun, Hongxia1; Wang, Lixia1; Li, Qian1; Guan, Aijiao1; Tang, Yalin1 |
| 刊名 | ANALYST
 |
| 出版日期 | 2015 |
| 卷号 | 140期号:5页码:1637-1646 |
| ISSN号 | 0003-2654 |
| DOI | 10.1039/c4an01912a |
| 英文摘要 | A series of dimeric cyanine dyes were designed to study their recognition for parallel c-myc G-quadruplex as well as their spectral features in solution. Dimeric cyanine dyes having different length linkers show their recognition for c-myc over duplex DNAs following the order: TC-P4 > TC-P5 > TC-P6 > TC-P3 > TC-P7 [the numeral is the number of repeat units (oligo-oxyethylene) in the linker]. This behaviour might result from their binding with G-quadruplex: the two chromophores of dimers stack on both ends of G-quadruplexes while the linker between two chromophores of dimers binds to the loops and grooves cooperatively. Further, these dyes presented an ability to differentiate the cervical cancer cell (Hela) from the normal cervical epithelial cell (CRL2614). These dyes have promising potential to be sensors to diagnose the G-quadruplex related diseases. |
| 语种 | 英语 |
| WOS记录号 | WOS:000349837200034 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53515]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Qianfan |
| 作者单位 | 1.Chinese Acad Sci ICCAS, Ctr Mol Sci, Inst Chem,Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Lijia,Yang, Qianfan,Xiang, Junfeng,et al. Targeting of parallel c-myc G-quadruplex by dimeric cyanine dye supramolecular assembly: dependence on the linker length[J]. ANALYST,2015,140(5):1637-1646. |
| APA | Yu, Lijia.,Yang, Qianfan.,Xiang, Junfeng.,Sun, Hongxia.,Wang, Lixia.,...&Tang, Yalin.(2015).Targeting of parallel c-myc G-quadruplex by dimeric cyanine dye supramolecular assembly: dependence on the linker length.ANALYST,140(5),1637-1646. |
| MLA | Yu, Lijia,et al."Targeting of parallel c-myc G-quadruplex by dimeric cyanine dye supramolecular assembly: dependence on the linker length".ANALYST 140.5(2015):1637-1646. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。