A facile and versatile strategy to efficiently synthesize sulfonated poly(butylene succinate), self-assembly behavior and biocompatibility
文献类型：期刊论文
| 作者 | Wu, Shaohua1,2; Zheng, Liuchun1; Li, Chuncheng1; Huo, Shuaidong2,3; Xiao, Yaonan1; Guan, Guohu1; Zhu, Wenxiang1 |
| 刊名 | POLYMER CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:9页码:1495-1501 |
| ISSN号 | 1759-9954 |
| DOI | 10.1039/c4py01305k |
| 英文摘要 | A series of amphiphilic and anionic copolyesters of sulfonated poly(butylene succinate) (SPBS) with sulfonate groups distributed randomly along the biodegradable backbone were synthesized via addition of sodium hydrogen sulphite to carbon-carbon double bonds on the backbone of poly(butylene succinate-co- butylene fumarate) (PBSF). The content of hydrophilic sulfonate groups can be facilely regulated by changing the initial feed ratio. The structures of PBSF and SPBS were systematically characterized by NMR and GPC. The negatively charged micelles self-assembled from SPBS were prepared by the dialysis method and characterized by NMR, DLS and TEM. In vitro cytotoxicity assay indicates that the SPBS micelles possess excellent biocompatibility. The biocompatibility of SPBS micelles increases with increasing content of sulfonate groups. This work provides a broad new method to facilely synthesize novel anionic copolyesters with high efficiency and controllable anion content. These copolyesters are highly promising as drug delivery carriers for cancer therapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000349832300008 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53523]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zheng, Liuchun |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Engn Plast, Beijing Natl Lab Mol Sci, Beijing 100080, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Shaohua,Zheng, Liuchun,Li, Chuncheng,et al. A facile and versatile strategy to efficiently synthesize sulfonated poly(butylene succinate), self-assembly behavior and biocompatibility[J]. POLYMER CHEMISTRY,2015,6(9):1495-1501. |
| APA | Wu, Shaohua.,Zheng, Liuchun.,Li, Chuncheng.,Huo, Shuaidong.,Xiao, Yaonan.,...&Zhu, Wenxiang.(2015).A facile and versatile strategy to efficiently synthesize sulfonated poly(butylene succinate), self-assembly behavior and biocompatibility.POLYMER CHEMISTRY,6(9),1495-1501. |
| MLA | Wu, Shaohua,et al."A facile and versatile strategy to efficiently synthesize sulfonated poly(butylene succinate), self-assembly behavior and biocompatibility".POLYMER CHEMISTRY 6.9(2015):1495-1501. |
入库方式： OAI收割
来源：化学研究所
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