Bioactive organic/inorganic hybrids with improved mechanical performance
文献类型：期刊论文
| 作者 | Li, Ailing1; Shen, Hong1; Ren, Huihui1; Wang, Chen1; Wu, Decheng1; Martin, Richard A.2,3; Qiu, Dong1 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2015 |
| 卷号 | 3期号:7页码:1379-1390 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c4tb01776e |
| 英文摘要 | New sol-gel functionalized poly-ethylene glycol (PEGM)/SiO2-CaO hybrids were prepared with interpenetrating networks of silica and PEGM through the formation of Si-O-Si bonds. Bioactive and mechanical properties were investigated for a series of hybrids containing varying organic/inorganic ratios and PEG molecular weights. In contrast to the unmodified PEG/SiO2-CaO hybrids, which rapidly dissolved and crumbled, the epoxy modified hybrids exhibited good mechanical properties and bioactivity. The compressive strength and Young's modulus were greater for higher molecular weight PEGM hybrids (PEGM600 compared to PEGM300). Compressive strengths of 138 MPa and 81 MPa were found for the 50 : 50 and 60 : 40 organic/inorganic hybrid samples respectively, which are comparable with cortical bone. Young's modulus values of similar to 800 MPa were obtained for the 50 : 50 and 60 : 40 organic/inorganic hybrids. Bioactivity tests were conducted by immersing the hybrids into simulated body fluid and observing the formation of apatite. Apatite formation was observed within 24 hours of immersion. PEGM600 hybrids showed enhanced apatite formation compared to PEGM300 hybrids. Increased apatite formation was observed with increasing organic/inorganic ratio. 70 : 30 and 60 : 40 hybrids exhibited the greatest apatite formation. All PEGM hybrids samples had good cell viability and proliferation. The 60 : 40 PEGM600 hybrids displayed the optimal combination of bioactivity and mechanical strength. The bioactivity of these hybrids, combined with the enhanced mechanical properties, demonstrate that these materials have significant potential for bone regeneration applications. |
| 语种 | 英语 |
| WOS记录号 | WOS:000349617600023 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53535]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Qiu, Dong |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Aston Univ, Sch Engn & Appl Sci, Birmingham B4 7ET, W Midlands, England 3.Aston Univ, Aston Res Ctr Hlth Ageing, Birmingham B4 7ET, W Midlands, England |
| 推荐引用方式 GB/T 7714 | Li, Ailing,Shen, Hong,Ren, Huihui,et al. Bioactive organic/inorganic hybrids with improved mechanical performance[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(7):1379-1390. |
| APA | Li, Ailing.,Shen, Hong.,Ren, Huihui.,Wang, Chen.,Wu, Decheng.,...&Qiu, Dong.(2015).Bioactive organic/inorganic hybrids with improved mechanical performance.JOURNAL OF MATERIALS CHEMISTRY B,3(7),1379-1390. |
| MLA | Li, Ailing,et al."Bioactive organic/inorganic hybrids with improved mechanical performance".JOURNAL OF MATERIALS CHEMISTRY B 3.7(2015):1379-1390. |
入库方式： OAI收割
来源：化学研究所
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