The Biological Performance of Calcium Hydroxide-loaded Microcapsules
文献类型：期刊论文
| 作者 | Han, Bing1; Wang, Xiaoyan1; Liu, Jiguang2; Liang, Fuxin2; Qu, Xiaozhong2; Yang, Zhenzhong2; Gao, Xuejun1 |
| 刊名 | JOURNAL OF ENDODONTICS
 |
| 出版日期 | 2013-08-01 |
| 卷号 | 39期号:8页码:1030-1034 |
| 关键词 | Biological Performance Calcium Hydroxide Controlled Release Microcapsules Sustained Release |
| ISSN号 | 0099-2399 |
| DOI | 10.1016/j.joen.2013.04.014 |
| 英文摘要 | Introduction: Calcium hydroxide (Ca[OH](2)) microcapsules were synthesized for use in controlled release. The aim of this study was to evaluate the cytotoxicity, antibacterial properties, and influence on gene expression of bone-related markers of 2 different formulas of Ca(OH)(2) microcapsules. Methods: Two formulas of Ca(OH)(2) microcapsules (A and B) were evaluated, and pure Ca(OH)(2) powder was used as a positive control. The shell material of formula A was pure EC, and the PLA/EC blend of 1:1 was used as the shell material for formula B. The MG63 cells/Cell Counting Kit-8 (Dojindo, Kumamoto, Japan) were used to evaluate the cytotoxicity, and the colony-forming units of Enterococcus faecalis were monitored for the antibacterial effect. The relative messenger RNA expression of collagen I and osteocalcin was determined by real-time polymerase chain reaction. Results: Both formulas of the Ca(OH)(2) microcapsules showed no cytotoxicity in MG63 cells; however, the Ca(OH)(2) positive control did exhibit cytotoxicity. The antibacterial effect of the 2 microcapsule formulas lasted longer than the positive control, and formula A lasted longer than formula B. For both Ca(OH)(2) microcapsule formulas, the relative messenger RNA expression of collagen I and osteocalcin was prolonged and up-regulated. The time effects of the influence on messenger RNA expression of collagen I and osteocalcin were different between the 2 microcapsule formulas. Conclusions: Ca(OH)(2) microcapsules had prolonged antibacterial activity and prolonged the up-regulation of bone-related markers with reduced cytotoxicity. |
| 语种 | 英语 |
| WOS记录号 | WOS:000323235600014 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53735]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Xiaoyan |
| 作者单位 | 1.Peking Univ, Sch & Hosp Stomatol, Dept Cariol & Endodontol, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Bing,Wang, Xiaoyan,Liu, Jiguang,et al. The Biological Performance of Calcium Hydroxide-loaded Microcapsules[J]. JOURNAL OF ENDODONTICS,2013,39(8):1030-1034. |
| APA | Han, Bing.,Wang, Xiaoyan.,Liu, Jiguang.,Liang, Fuxin.,Qu, Xiaozhong.,...&Gao, Xuejun.(2013).The Biological Performance of Calcium Hydroxide-loaded Microcapsules.JOURNAL OF ENDODONTICS,39(8),1030-1034. |
| MLA | Han, Bing,et al."The Biological Performance of Calcium Hydroxide-loaded Microcapsules".JOURNAL OF ENDODONTICS 39.8(2013):1030-1034. |
入库方式： OAI收割
来源：化学研究所
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