Synthesis and bio-evaluation of novel hypocrellin derivatives: Potential photosensitizers for photodynamic therapy of age-related macular degeneration
文献类型：期刊论文
| 作者 | Deng, Hong1; Li, Tinghui2; Xie, Jie1; Huang, Naiyan3; Gu, Ying3; Zhao, Jingquan1 |
| 刊名 | DYES AND PIGMENTS
 |
| 出版日期 | 2013-12-01 |
| 卷号 | 99期号:3页码:930-939 |
| 关键词 | Hypocrellin Derivatives Age-related Macular Degeneration Target Characters Phototherapeutic Window Drug-delivery Biological Activity |
| ISSN号 | 0143-7208 |
| DOI | 10.1016/j.dyepig.2013.06.037 |
| 英文摘要 | The phototherapeutic window from 600 to 900 nm is necessary for photodynamic therapy (PDT) of solid tumors, but may not suitable for PDT of some microvascular diseases, like age-related macular degeneration (AMD), because of its deep penetration. Moreover, absorption of some neighboring photoreceptors should be avoided for PDT of AMD. Considering these, yellow-orange light may be a proper phototherapeutic window of AMD. Herein, two novel amino-alkyl-sulfonic acid-substituted hypocrellin B derivatives, 3 and 4 were designed and synthesized. They exhibited the maximal absorption at yellow-orange light, and possessed higher PDT activity than 2, proved by the in vitro or in vivo experiments. Besides, 4 showed much higher PDT activity than 3, ascribed to its higher cellular uptake suggested by its optimized amphiphilicity and liposome mimic results. And the vascular leakage of 4 was close to 2. Consequently, 4 has great potential for PDT of AMD or other superficial diseases. (C) 2013 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000327560200055 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53743]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, Jingquan |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Photochem, Beijing Natl Lab Mol Sci BNLMS, Beijing 100190, Peoples R China 2.PLA, Hosp 309, Dept Dermatol, Beijing 100091, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Hong,Li, Tinghui,Xie, Jie,et al. Synthesis and bio-evaluation of novel hypocrellin derivatives: Potential photosensitizers for photodynamic therapy of age-related macular degeneration[J]. DYES AND PIGMENTS,2013,99(3):930-939. |
| APA | Deng, Hong,Li, Tinghui,Xie, Jie,Huang, Naiyan,Gu, Ying,&Zhao, Jingquan.(2013).Synthesis and bio-evaluation of novel hypocrellin derivatives: Potential photosensitizers for photodynamic therapy of age-related macular degeneration.DYES AND PIGMENTS,99(3),930-939. |
| MLA | Deng, Hong,et al."Synthesis and bio-evaluation of novel hypocrellin derivatives: Potential photosensitizers for photodynamic therapy of age-related macular degeneration".DYES AND PIGMENTS 99.3(2013):930-939. |
入库方式： OAI收割
来源：化学研究所
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