An effective strategy for the synthesis of biocompatible gold nanoparticles using danshensu antioxidant: prevention of cytotoxicity via attenuation of free radical formation
文献类型：期刊论文
| 作者 | Du, Libo1; Miao, Xiaoxiang1; Jiang, Yugang1; Jia, Hongying1; Tian, Qiu1; Shen, Jiangang2; Liu, Yang1 |
| 刊名 | NANOTOXICOLOGY
 |
| 出版日期 | 2013-05-01 |
| 卷号 | 7期号:3页码:294-300 |
| 关键词 | Nanoparticles Oxidative Stress Antioxidant Free Radicals Cell Toxicity |
| ISSN号 | 1743-5390 |
| DOI | 10.3109/17435390.2011.653415 |
| 英文摘要 | To suppress the cytotoxicity of gold nanoparticles (AuNPs), danshensu, a naturally occurring polyphenol antioxidant isolated from Chinese herb, was used to provide a fundamental protection layer for AuNPs, to alleviate oxidative stress and as a reducing agent to react with chloroauric acid. Besides danshensu, gum arabic was chosen as an auxiliary stabilising agent to improve the stability of AuNPs against aggregation. As expected, the prepared GA-DS-AuNPs (gum arabic-danshensugold nanoparticle) was remarkably stable in various buffer solutions. More interestingly, the GA-DS-AuNPs not only did not show any appreciable cytotoxicity, but also could alleviate the oxidative damage induced by AuNPs. Meanwhile, the ROS/RNS scavenging activities of GA-DS-AuNPs was evaluated by electron spin resonance spectroscopy (ESR), potentiometric nitric oxide (NO) sensor and cell confocal imaging. The results suggest that GA-DS-AuNPs might have effectively reduced the AuNPs-induced cytotoxicity and oxidative stress by downregulation of ROS/ NOS production. The GA-DS-AuNPs may provide potential opportunities for the application in nanomedicine and nanobiology. |
| 语种 | 英语 |
| WOS记录号 | WOS:000317497000005 |
| 出版者 | INFORMA HEALTHCARE |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53781]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Yang |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100080, Peoples R China 2.Univ Hong Kong, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Libo,Miao, Xiaoxiang,Jiang, Yugang,et al. An effective strategy for the synthesis of biocompatible gold nanoparticles using danshensu antioxidant: prevention of cytotoxicity via attenuation of free radical formation[J]. NANOTOXICOLOGY,2013,7(3):294-300. |
| APA | Du, Libo.,Miao, Xiaoxiang.,Jiang, Yugang.,Jia, Hongying.,Tian, Qiu.,...&Liu, Yang.(2013).An effective strategy for the synthesis of biocompatible gold nanoparticles using danshensu antioxidant: prevention of cytotoxicity via attenuation of free radical formation.NANOTOXICOLOGY,7(3),294-300. |
| MLA | Du, Libo,et al."An effective strategy for the synthesis of biocompatible gold nanoparticles using danshensu antioxidant: prevention of cytotoxicity via attenuation of free radical formation".NANOTOXICOLOGY 7.3(2013):294-300. |
入库方式： OAI收割
来源：化学研究所
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