AC-electrokinetic manipulation and controlled encapsulate release of surfactant based micelles
文献类型：期刊论文
| 作者 | Goodrich, Victoria E.1; Connor, Erin1; Wang, Shengqin1; Yang, Jingfa3; Zhao, Jiang3; Zhu, Yingxi1,2 |
| 刊名 | SOFT MATTER
 |
| 出版日期 | 2013 |
| 卷号 | 9期号:20页码:5052-5060 |
| ISSN号 | 1744-683X |
| DOI | 10.1039/c3sm00014a |
| 英文摘要 | Effective manipulation and understanding of the dynamic responses of complex micelle nanocolloids under ac-electric fields is of great scientific and technological importance due to the emerging interest in using rich electrokinetic phenomena for medical diagnostics and drug delivery. In this work, we employ fluorescence correlation spectroscopy (FCS) to study the ac-electrokinetic behaviors of surfactant-based micelles encapsulated with varied fluorescence and model drug probes at a single micelle level. Under applied non-uniform ac-fields of constant voltage across two adjacent microelectrodes in a quadrupole configuration, probe-encapsulated micelles exhibit positive dielectrophoresis (DEP) characteristics at the ac-frequency range of 10-500 kHz, in contrast to negative or zero DEP at higher frequency of approximately greater than 500 kHz. The transition from positive to negative or zero DEP is indicated by the field-induced decrease of micelle concentration in the FCS focal volume located in the high field regions between two adjacent microelectrodes. The estimated DEP crossover frequency from omega-dependent micelle concentration profile agrees with advanced DEP theory, which predicts the scaling of crossover frequency with Stern layer conductance. At a lower frequency range of omega 5-10 kHz, unique and surprising response in the measured fluorescence autocorrelation functions of charged probe-encapsulated micelles is observed, but not so with neutral encapsulated probes, suggesting ac-field induced micelle instability with the resulting release of interior charged probe encapsulates. Intriguingly, the release of encapsulates from micelles by non-uniform ac-electric fields shows strong dependence on ac-frequency and encapsulate chemistry. |
| 语种 | 英语 |
| WOS记录号 | WOS:000318360100013 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53805]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhu, Yingxi |
| 作者单位 | 1.Univ Notre Dame, Dept Chem & Biomol Engn, Notre Dame, IN 46556 USA 2.Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA 3.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Goodrich, Victoria E.,Connor, Erin,Wang, Shengqin,et al. AC-electrokinetic manipulation and controlled encapsulate release of surfactant based micelles[J]. SOFT MATTER,2013,9(20):5052-5060. |
| APA | Goodrich, Victoria E.,Connor, Erin,Wang, Shengqin,Yang, Jingfa,Zhao, Jiang,&Zhu, Yingxi.(2013).AC-electrokinetic manipulation and controlled encapsulate release of surfactant based micelles.SOFT MATTER,9(20),5052-5060. |
| MLA | Goodrich, Victoria E.,et al."AC-electrokinetic manipulation and controlled encapsulate release of surfactant based micelles".SOFT MATTER 9.20(2013):5052-5060. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。