Characterization and Minimization of Block Copolypeptide Vesicle Cytotoxicity Using Different Hydrophobic Chain Lengths
文献类型：期刊论文
| 作者 | Choe, Uh-Joo1; Rodriguez, April R.1; Li, Zhibo2; Boyarskiy, Sergey3; Deming, Timothy J.1; Kamei, Daniel T.1 |
| 刊名 | MACROMOLECULAR CHEMISTRY AND PHYSICS
 |
| 出版日期 | 2013-05-14 |
| 卷号 | 214期号:9页码:994-999 |
| 关键词 | Block Copolypeptides Micelles Oligoleucines Peptides Vesicles |
| ISSN号 | 1022-1352 |
| DOI | 10.1002/macp.201200591 |
| 英文摘要 | The previously reported amphiphilic block copolypeptide, poly(l-lysine)60-block-poly(l-leucine)20 (K60L20), is able to form vesicles that can be manipulated to different sizes and be prepared in large quantities. This study expands upon that work by varying the length of the hydrophobic segment to optimize the vesicles so that they are monodisperse and low in toxicity. Copolypeptides with longer oligoleucine segments are found to have fewer toxic micelles, small aggregates, and unstable vesicles, and exhibit lower toxicity than vesicles formed from copolypeptides with shorter hydrophobic domains. Oligoleucine segments that are too long, however, result in rigid hydrophobic membranes that prevent the vesicular assemblies from being extruded into a monodisperse population of nanoscale vesicles. |
| 语种 | 英语 |
| WOS记录号 | WOS:000318353900005 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53855]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Kamei, Daniel T. |
| 作者单位 | 1.Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA 2.Chinese Acad Sci, Inst Chem, Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 3.Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA |
| 推荐引用方式 GB/T 7714 | Choe, Uh-Joo,Rodriguez, April R.,Li, Zhibo,et al. Characterization and Minimization of Block Copolypeptide Vesicle Cytotoxicity Using Different Hydrophobic Chain Lengths[J]. MACROMOLECULAR CHEMISTRY AND PHYSICS,2013,214(9):994-999. |
| APA | Choe, Uh-Joo,Rodriguez, April R.,Li, Zhibo,Boyarskiy, Sergey,Deming, Timothy J.,&Kamei, Daniel T..(2013).Characterization and Minimization of Block Copolypeptide Vesicle Cytotoxicity Using Different Hydrophobic Chain Lengths.MACROMOLECULAR CHEMISTRY AND PHYSICS,214(9),994-999. |
| MLA | Choe, Uh-Joo,et al."Characterization and Minimization of Block Copolypeptide Vesicle Cytotoxicity Using Different Hydrophobic Chain Lengths".MACROMOLECULAR CHEMISTRY AND PHYSICS 214.9(2013):994-999. |
入库方式： OAI收割
来源：化学研究所
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