Polyamidoamine dendrimer conjugated chitosan nanoparticles for the delivery of methotrexate
文献类型：期刊论文
| 作者 | Leng, Zhen-Hua1,2; Zhuang, Qian-Fen2; Li, Yan-Chao2; He, Zeng3,4; Chen, Zhao2; Huang, Sai-Peng2; Jia, Hong-Ying2; Zhou, Jian-Wei1; Liu, Yang2; Du, Li-Bo2 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2013-10-15 |
| 卷号 | 98期号:1页码:1173-1178 |
| 关键词 | Chitosan Nanoparticles Pamam Drug Delivery Methotrexate |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2013.07.021 |
| 英文摘要 | Encapsulating anticancer drugs to synthetic polymer is a promising approach to improve the efficiency and reduce the side effects of anticancer drugs. In this study, novel chitosan derivatives with polyamidoamine moieties (CS-PAMAM) were synthesized and characterized by morphology, particle size, and zeta potential. Then the anticancer drug-methotrexate-encapsulated CS-PAMAM was prepared by hydrophobic-hydrophilic interactions. The drug release assay showed that the amount of the methotrexate release from CS-PAMAM was pH depended. Meanwhile, the cell viability assay illustrated that CS-PAMAM was suitable for the drug delivery because of its low cytotoxicity on cells. Moreover, our results showed that the CS-PAMAM could significantly improve the cytotoxicity of free methotrexate on A549 cells. These results demonstrate that CS-PAMAM may provide a suitable platform for the water-insoluble drug delivery. (C) 2013 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000325835600151 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53883]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhou, Jian-Wei |
| 作者单位 | 1.Guizhou Normal Univ, Sch Chem & Mat Sci, Guiyang, Guizhou, Peoples R China 2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100080, Peoples R China 3.Chinese Acad Med Sci, Inst Blood Transfus, Chengdu, Sichuan, Peoples R China 4.Peking Union Med Coll, Chengdu, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Leng, Zhen-Hua,Zhuang, Qian-Fen,Li, Yan-Chao,et al. Polyamidoamine dendrimer conjugated chitosan nanoparticles for the delivery of methotrexate[J]. CARBOHYDRATE POLYMERS,2013,98(1):1173-1178. |
| APA | Leng, Zhen-Hua.,Zhuang, Qian-Fen.,Li, Yan-Chao.,He, Zeng.,Chen, Zhao.,...&Du, Li-Bo.(2013).Polyamidoamine dendrimer conjugated chitosan nanoparticles for the delivery of methotrexate.CARBOHYDRATE POLYMERS,98(1),1173-1178. |
| MLA | Leng, Zhen-Hua,et al."Polyamidoamine dendrimer conjugated chitosan nanoparticles for the delivery of methotrexate".CARBOHYDRATE POLYMERS 98.1(2013):1173-1178. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。