Platelet Aggregation Pathway Network-Based Approach for Evaluating Compounds Efficacy
文献类型：期刊论文
| 作者 | Gu, Jiangyong1; Li, Qian1,2; Chen, Lirong1; Li, Youyong3; Hou, Tingjun3; Yuan, Gu1; Xu, Xiaojie1 |
| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| 出版日期 | 2013 |
| ISSN号 | 1741-427X |
| DOI | 10.1155/2013/425707 |
| 英文摘要 | Traditional Chinese medicines (TCMs) contain a large quantity of compounds with multiple biological activities. By using multitargets docking and network analysis in the context of pathway network of platelet aggregation, we proposed network efficiency and network flux model to screen molecules which can be used as drugs for antiplatelet aggregation. Compared with traditional single-target screening methods, network efficiency and network flux take into account the influences which compounds exert on the whole pathway network. The activities of antiplatelet aggregation of 19 active ingredients separated from TCM and 14 nonglycoside compounds predicated from network efficiency and network flux model show good agreement with experimental results (correlation coefficient = 0.73 and 0.90, resp.). This model can be used to evaluate the potential bioactive compounds and thus bridges the gap between computation and clinical indicator. |
| 语种 | 英语 |
| WOS记录号 | WOS:000317512600001 |
| 出版者 | HINDAWI PUBLISHING CORPORATION |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/53983]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Lirong |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, BNLMS, State Key Lab Rare Earth Mat Chem & Applicat, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, BNLMS,Ctr Mol Sci, Beijing 100190, Peoples R China 3.Soochow Univ, Inst Funct Nano, Suzhou 215123, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, Jiangyong,Li, Qian,Chen, Lirong,et al. Platelet Aggregation Pathway Network-Based Approach for Evaluating Compounds Efficacy[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013. |
| APA | Gu, Jiangyong.,Li, Qian.,Chen, Lirong.,Li, Youyong.,Hou, Tingjun.,...&Xu, Xiaojie.(2013).Platelet Aggregation Pathway Network-Based Approach for Evaluating Compounds Efficacy.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. |
| MLA | Gu, Jiangyong,et al."Platelet Aggregation Pathway Network-Based Approach for Evaluating Compounds Efficacy".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013). |
入库方式： OAI收割
来源：化学研究所
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