Total Synthesis and Glycosidase Inhibition of Broussonetine I and J(2)
文献类型：期刊论文
| 作者 | Zhao, Hui1,3; Kato, Atsushi2; Sato, Kasumi2; Jia, Yue-Mei1; Yu, Chu-Yi1 |
| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2013-08-16 |
| 卷号 | 78期号:16页码:7896-7902 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/jo4010553 |
| 英文摘要 | The first total synthesis of both broussonetine I and J(2) together with their enantiomers have been accomplished via the same synthetic route through 18 and 16 steps in excellent overall yields (18% and 19%, respectively), starting from R-glyceraldehyde. Broussonetine I was found to be a potent inhibitor of beta-glucosidase (IC50 = 2.9 mu M), while ent-broussonetine I and ent-broussonetine J(2) were found to be potent inhibitors of alpha-glucosidase (IC50 = 0.33 and 0.53 mu M, respectively). |
| 语种 | 英语 |
| WOS记录号 | WOS:000323362600010 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/54025]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yu, Chu-Yi |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, BNLMS, Beijing 100190, Peoples R China 2.Toyama Univ, Dept Hosp Pharm, Toyama 9300194, Japan 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Hui,Kato, Atsushi,Sato, Kasumi,et al. Total Synthesis and Glycosidase Inhibition of Broussonetine I and J(2)[J]. JOURNAL OF ORGANIC CHEMISTRY,2013,78(16):7896-7902. |
| APA | Zhao, Hui,Kato, Atsushi,Sato, Kasumi,Jia, Yue-Mei,&Yu, Chu-Yi.(2013).Total Synthesis and Glycosidase Inhibition of Broussonetine I and J(2).JOURNAL OF ORGANIC CHEMISTRY,78(16),7896-7902. |
| MLA | Zhao, Hui,et al."Total Synthesis and Glycosidase Inhibition of Broussonetine I and J(2)".JOURNAL OF ORGANIC CHEMISTRY 78.16(2013):7896-7902. |
入库方式： OAI收割
来源：化学研究所
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