Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells
文献类型：期刊论文
| 作者 | Yang, Yong1; Wolfram, Joy1; Boom, Kathryn1; Fang, Xiaohong2; Shen, Haifa1,3; Ferrari, Mauro1,4 |
| 刊名 | CELL BIOCHEMISTRY AND FUNCTION
 |
| 出版日期 | 2013-07-01 |
| 卷号 | 31期号:5页码:374-379 |
| 关键词 | Hesperetin Glucose Uptake Glut1 Glut4 Breast Cancer Cells |
| ISSN号 | 0263-6484 |
| DOI | 10.1002/cbf.2905 |
| 英文摘要 | The flavanone hesperetin is known to decrease basal glucose uptake, although the inhibitory mechanism is largely unknown. Here, we used MDA-MB-231 breast cancer cells to investigate the molecular pathways affected by hesperetin. The results indicate that the suppression of glucose uptake is caused by the down-regulation of glucose transporter 1 (GLUT1). Hesperetin was also found to inhibit insulin-induced glucose uptake through impaired cell membrane translocation of glucose transporter 4 (GLUT4). In addition, the phosphorylation of the insulin receptor-beta subunit (IR-beta) and Akt was suppressed. Hesperetin also decreased cellular proliferation, which is likely due to the inhibition of glucose uptake. Cancer cells are highly dependent on glucose and hesperetin may, therefore, have potential application as an anticancer agent. Copyright (c) 2012 John Wiley & Sons, Ltd. |
| 语种 | 英语 |
| WOS记录号 | WOS:000322154400003 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/54061]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Ferrari, Mauro |
| 作者单位 | 1.Methodist Hosp, Res Inst, Dept Nanomed, Houston, TX 77030 USA 2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China 3.Weill Cornell Med Coll, Dept Cell & Dev Biol, New York, NY USA 4.Weill Cornell Med Coll, Dept Med, New York, NY USA |
| 推荐引用方式 GB/T 7714 | Yang, Yong,Wolfram, Joy,Boom, Kathryn,et al. Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells[J]. CELL BIOCHEMISTRY AND FUNCTION,2013,31(5):374-379. |
| APA | Yang, Yong,Wolfram, Joy,Boom, Kathryn,Fang, Xiaohong,Shen, Haifa,&Ferrari, Mauro.(2013).Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells.CELL BIOCHEMISTRY AND FUNCTION,31(5),374-379. |
| MLA | Yang, Yong,et al."Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells".CELL BIOCHEMISTRY AND FUNCTION 31.5(2013):374-379. |
入库方式： OAI收割
来源：化学研究所
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