A Versatile and Robust Vesicle Based on a Photocleavable Surfactant for Two-Photon-Tuned Release
文献类型：期刊论文
| 作者 | Dong, Jianming1; Xun, Zhiqing1; Zeng, Yi1; Yu, Tianjun1; Han, Yongbin1; Chen, Jinping1; Li, Ying-Ying1; Yang, Guoqiang2; Li, Yi1 |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2013-06-01 |
| 卷号 | 19期号:24页码:7931-7936 |
| 关键词 | Amphiphiles Controlled Release Drug Delivery Host-guest Systems Vesicles |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.201300526 |
| 英文摘要 | A small amphiphile that contains a coumarin unit and alkynyl groups, as a two-photon-cleavable segment and polymerizable groups, respectively, was designed and synthesized. The amphiphile showed a critical aggregation concentration of about 4.6x10-5M and formed a vesicle-type assembly. The formed vesicles were stabilized by insitu click polymerization without altering their morphology. Hydrophobic and hydrophilic guests can be encapsulated within the vesicle membrane and inside the aqueous core of the vesicle, respectively. The loaded guests can be released from the vesicle by using UV or near-IR stimuli, through splitting up the amphiphilic structure of the amphiphile. Distinguished dose-controlled photorelease of the polymeric vesicle is achieved with the maintenance of vesicular integrity, which makes the guest release dependent on the amount of cleavage of the amphiphilic structure during irradiation. This study provides a potential strategy for the development of versatile and stable drug-delivery systems that offer sustained and photo-triggered release. |
| 语种 | 英语 |
| WOS记录号 | WOS:000319825500034 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/54083]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zeng, Yi |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Chem, Key Lab Photochem, Beijing Natl Lab Mol Sci BNLMS, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Jianming,Xun, Zhiqing,Zeng, Yi,et al. A Versatile and Robust Vesicle Based on a Photocleavable Surfactant for Two-Photon-Tuned Release[J]. CHEMISTRY-A EUROPEAN JOURNAL,2013,19(24):7931-7936. |
| APA | Dong, Jianming.,Xun, Zhiqing.,Zeng, Yi.,Yu, Tianjun.,Han, Yongbin.,...&Li, Yi.(2013).A Versatile and Robust Vesicle Based on a Photocleavable Surfactant for Two-Photon-Tuned Release.CHEMISTRY-A EUROPEAN JOURNAL,19(24),7931-7936. |
| MLA | Dong, Jianming,et al."A Versatile and Robust Vesicle Based on a Photocleavable Surfactant for Two-Photon-Tuned Release".CHEMISTRY-A EUROPEAN JOURNAL 19.24(2013):7931-7936. |
入库方式： OAI收割
来源：化学研究所
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