中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Biocompatibility evaluation of aniline oligomers with different end-functional groups

文献类型:期刊论文

作者Qi, Hongxu1; Liu, Meiying2; Xu, Liangxin1; Feng, Lin1; Tao, Lei1; Ji, Yan1; Zhang, Xiaoyong1; Wei, Yen1
刊名TOXICOLOGY RESEARCH
出版日期2013
卷号2期号:6页码:427-433
ISSN号2045-452X
DOI10.1039/c3tx50060h
英文摘要With the ever increasing interest in biomedical applications of aniline oligomers, carefully and systematically evaluating their biocompatibility is of significant importance. In this paper, aniline oligomers with different end-functional groups (tetramer terminated with gluocose (T-G), pentamer terminated with amino group (P-NH2) and pentamer terminated with carboxyl group (P-COOH)) were synthesized. Their cellular responses to adenocarcinomic human alveolar basal epithelial (A549) cells and human cervical carcinoma (HeLa) cells were investigated for the first time. To verify their potential for in vivo biomedical applications, the interactions between aniline oligomers and red blood cells (RBCs) were further examined. Results indicated that end groups of oligomers affected their cell response. Among all tested molecules, T-G showed the greatest cytotoxicity to both types of cells. Compared with HeLa cells, all oligomers exhibited better biocompatibility with A549 cells. Furthermore, the cell membrane of RBCs was still kept intact after incubation with aniline oligomers for over 4 h, indicating that the cytotoxicity of aniline oligomers was not due to the rupture of the cell membrane. We expect that these results could be helpful to understand the cytotoxicity of aniline oligomers and may give valuable instructions to design biocompatible aniline oligomers for biomedical applications.
语种英语
WOS记录号WOS:000325370800007
出版者ROYAL SOC CHEMISTRY
源URL[http://ir.iccas.ac.cn/handle/121111/54263]  
专题中国科学院化学研究所
通讯作者Qi, Hongxu
作者单位1.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
2.Chinese Acad Sci, BNLMS, Key Lab Organ Solids, New Mat Lab,Inst Chem, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Qi, Hongxu,Liu, Meiying,Xu, Liangxin,et al. Biocompatibility evaluation of aniline oligomers with different end-functional groups[J]. TOXICOLOGY RESEARCH,2013,2(6):427-433.
APA Qi, Hongxu.,Liu, Meiying.,Xu, Liangxin.,Feng, Lin.,Tao, Lei.,...&Wei, Yen.(2013).Biocompatibility evaluation of aniline oligomers with different end-functional groups.TOXICOLOGY RESEARCH,2(6),427-433.
MLA Qi, Hongxu,et al."Biocompatibility evaluation of aniline oligomers with different end-functional groups".TOXICOLOGY RESEARCH 2.6(2013):427-433.

入库方式: OAI收割

来源:化学研究所

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