Novel 2-aryl-3,4,5-trihydroxypiperidines: Synthesis and glycosidase inhibition
文献类型：期刊论文
| 作者 | Zhao, Hui1; Wang, Wu-Bao1; Nakagawa, Shinpei2; Jia, Yue-Mei1; Hu, Xiang-Guo1; Fleet, George W. J.3; Wilson, Francis X.4; Nash, Robert J.5; Kato, Atsushi2; Yu, Chu-Yi1 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2013-12-01 |
| 卷号 | 24期号:12页码:1059-1063 |
| 关键词 | 2-aryl Polyhydroxylated Piperidine Iminosugars Radicamine Mimics Glycosidase Inhibitors |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2013.06.027 |
| 英文摘要 | Three pairs of novel 2-aryl-3,4,5-trihydroxypiperidines (6-8 and their enantiomers), the piperidine analogues of the pyrrolidine alkaloids radicamine A and radicamine B, were prepared from six-membered cyclic nitrones through a concise two-step procedure, i.e., Grignard reagent addition and deprotection. These novel polyhydroxylated piperidine iminosugars were assayed against 10 types of enzymes. Only compound 8 exhibited weak inhibition (IC50 1080 mu mol/L) against beta-galactosidase from rat intestinal lactases. (C) 2013 Atsushi Kato and Chu-Yi Yu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000329019000006 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/54345]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Kato, Atsushi |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China 2.Toyama Univ, Dept Hosp Pharm, Toyama 9300194, Japan 3.Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England 4.Summit PLC, Abingdon OX14 4RY, Oxon, England 5.Phytoquest Ltd, IBERS, Aberystwyth SY23 3EB, Dyfed, Wales |
| 推荐引用方式 GB/T 7714 | Zhao, Hui,Wang, Wu-Bao,Nakagawa, Shinpei,et al. Novel 2-aryl-3,4,5-trihydroxypiperidines: Synthesis and glycosidase inhibition[J]. CHINESE CHEMICAL LETTERS,2013,24(12):1059-1063. |
| APA | Zhao, Hui.,Wang, Wu-Bao.,Nakagawa, Shinpei.,Jia, Yue-Mei.,Hu, Xiang-Guo.,...&Yu, Chu-Yi.(2013).Novel 2-aryl-3,4,5-trihydroxypiperidines: Synthesis and glycosidase inhibition.CHINESE CHEMICAL LETTERS,24(12),1059-1063. |
| MLA | Zhao, Hui,et al."Novel 2-aryl-3,4,5-trihydroxypiperidines: Synthesis and glycosidase inhibition".CHINESE CHEMICAL LETTERS 24.12(2013):1059-1063. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。