Dual-Responsive Surfaces Modified with Phenylboronic Acid-Containing Polymer Brush To Reversibly Capture and Release Cancer Cells
文献类型：期刊论文
| 作者 | Liu, Hongliang1; Li, Yingying1; Sun, Kang1; Fan, Junbing1; Zhang, Pengchao1,2; Meng, Jingxin1; Wang, Shutao1; Jiang, Lei1 |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2013-05-22 |
| 卷号 | 135期号:20页码:7603-7609 |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/ja401000m |
| 英文摘要 | Artificial stimuli-responsive surfaces that can mimic the dynamic function of living systems have attracted much attention. However, there exist few artificial systems capable of responding to dual- or multistimulation as the natural system does. Herein, we synthesize a pH and glucose dual-responsive surface by grafting poly(acrylamidophenylboronic acid) (polyAAPBA) brush from aligned silicon nanowire (SiNW) array. The as-prepared surface can reversibly capture and release targeted cancer cells by precisely controlling pH and glucose concentration, exhibiting dual-responsive AND logic. In the presence of 70 mM glucose, the surface is pH responsive, which can vary from a cell-adhesive state to a cell-repulsive state by changing the pH from 6.8 to 7.8. While keeping the pH at 7.8, the surface becomes glucose responsive-capturing cells in the absence of glucose and releasing cells by adding 70 mM glucose. Through simultaneously changing the pH and glucose concentration from pH 6.8/0 mM glucose to pH 7.8/70 mM glucose, the surface is dual responsive with the capability to switch between cell capture and release for at least 5 cycles. The cell capture and release process on this dual-responsive surface is noninvasive with cell viability higher than 95%. Moreover, topographical interaction between the aligned SiNW array and cell protrusions greatly amplifies the responsiveness and accelerates the response rate of the dual-responsive surface between cell capture and release. The responsive mechanism of the dual-responsive surface is systematically studied using a quartz crystal microbalance, which shows that the competitive binding between polyAAPBA/sialic acid and polyAAPBA/glucose contributes to the dual response. Such dual-responsive surface can significantly impact biomedical and biological applications including cell-based diagnostics, in vivo drug delivery, etc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000319551000033 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/54463]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Shutao |
| 作者单位 | 1.Chinese Acad Sci, BNLMS, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Hongliang,Li, Yingying,Sun, Kang,et al. Dual-Responsive Surfaces Modified with Phenylboronic Acid-Containing Polymer Brush To Reversibly Capture and Release Cancer Cells[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2013,135(20):7603-7609. |
| APA | Liu, Hongliang.,Li, Yingying.,Sun, Kang.,Fan, Junbing.,Zhang, Pengchao.,...&Jiang, Lei.(2013).Dual-Responsive Surfaces Modified with Phenylboronic Acid-Containing Polymer Brush To Reversibly Capture and Release Cancer Cells.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,135(20),7603-7609. |
| MLA | Liu, Hongliang,et al."Dual-Responsive Surfaces Modified with Phenylboronic Acid-Containing Polymer Brush To Reversibly Capture and Release Cancer Cells".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 135.20(2013):7603-7609. |
入库方式： OAI收割
来源：化学研究所
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