Facile Synthesis of Dendrimers Combining aza-Michael Addition with Thiol-yne Click Chemistry
文献类型：期刊论文
| 作者 | Shen, Yong; Ma, Yinan; Li, Zhibo |
| 刊名 | JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
 |
| 出版日期 | 2013-02-01 |
| 卷号 | 51期号:3页码:708-715 |
| 关键词 | Branched Biomaterials Dendrimers Michael Addition Thiol-yne |
| ISSN号 | 0887-624X |
| DOI | 10.1002/pola.26429 |
| 英文摘要 | We report a highly efficient approach to prepare dendrimers by taking advantage of the orthogonal characteristic of aza-Michael addition and thiol-yne reactions. A fifth generation dendrimer was synthesized within five steps without protection/activation procedures. The reactions proceed under benign conditions without byproducts, and the target products can be easily purified via extraction or precipitation without chromatography. The structure of each generation dendrimer was characterized using NMR spectroscopy, size exclusion chromatography, and mass spectrometry. The obtained dendrimers can have peripheral amine or alkyne groups. We demonstrated that these groups can be used for selective and specific conjugation with various functional groups. (C) 2012 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 708-715 |
| 语种 | 英语 |
| WOS记录号 | WOS:000314149000023 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/54501]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Zhibo |
| 作者单位 | Chinese Acad Sci, Inst Chem, BNLMS, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Yong,Ma, Yinan,Li, Zhibo. Facile Synthesis of Dendrimers Combining aza-Michael Addition with Thiol-yne Click Chemistry[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2013,51(3):708-715. |
| APA | Shen, Yong,Ma, Yinan,&Li, Zhibo.(2013).Facile Synthesis of Dendrimers Combining aza-Michael Addition with Thiol-yne Click Chemistry.JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,51(3),708-715. |
| MLA | Shen, Yong,et al."Facile Synthesis of Dendrimers Combining aza-Michael Addition with Thiol-yne Click Chemistry".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 51.3(2013):708-715. |
入库方式： OAI收割
来源：化学研究所
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