A tough hydrogel-hydroxyapatite bone-like composite fabricated in situ by the electrophoresis approach
文献类型：期刊论文
| 作者 | Li, Zhiyong1,2; Su, Yunlan2; Xie, Baoquan2; Wang, Huiliang1; Wen, Tao2; He, Changcheng1; Shen, Hong3; Wu, Decheng3; Wang, Dujin2 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2013 |
| 卷号 | 1期号:12页码:1755-1764 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c3tb00246b |
| 英文摘要 | Mechanically strong hydrogel-HAp composites have been successfully fabricated through in situ formation of hydroxyapatite (HAp) in a tough polyacrylamide (PAAm) hydrogel with a modified electrophoretic mineralization method. The pre-swelling of the PAAm hydrogels in CaCl2 buffer solutions makes the electrophoresis method able to produce large area (10 x 8 cm(2)) hydrogel-HAp composites. At the same time the CaCl2 solution with different concentrations could control the HAp contents. The obtained hydrogel-HAp composites exhibit enhanced mechanical properties, namely higher extensibility (>2000%), tensile strength (0.1-1.0 MPa) and compressive strength (up to 35 MPa), in comparison to the as-synthesized PAAm hydrogels. FTIR and Raman characterizations indicate the formation of strong interactions between PAAm chains and HAp particles, which are thought to be the main reason for the enhanced mechanical properties. The hydrogel-HAp composite also shows excellent osteoblast cell adhesion properties. These composite materials may find more applications in biomedical areas, e.g. as a matrix for tissue repair especially for orthopedic applications and bone tissue engineering. |
| 语种 | 英语 |
| WOS记录号 | WOS:000315412300011 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/54507]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Zhiyong |
| 作者单位 | 1.Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Engn Plast, Inst Chem, Beijing 100190, Peoples R China 3.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhiyong,Su, Yunlan,Xie, Baoquan,et al. A tough hydrogel-hydroxyapatite bone-like composite fabricated in situ by the electrophoresis approach[J]. JOURNAL OF MATERIALS CHEMISTRY B,2013,1(12):1755-1764. |
| APA | Li, Zhiyong.,Su, Yunlan.,Xie, Baoquan.,Wang, Huiliang.,Wen, Tao.,...&Wang, Dujin.(2013).A tough hydrogel-hydroxyapatite bone-like composite fabricated in situ by the electrophoresis approach.JOURNAL OF MATERIALS CHEMISTRY B,1(12),1755-1764. |
| MLA | Li, Zhiyong,et al."A tough hydrogel-hydroxyapatite bone-like composite fabricated in situ by the electrophoresis approach".JOURNAL OF MATERIALS CHEMISTRY B 1.12(2013):1755-1764. |
入库方式： OAI收割
来源：化学研究所
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