Immobilization of radionuclides on poly(lactide-co-glycolide) nanofibrous membranes
文献类型：期刊论文
| 作者 | Nie, Huarong1; He, Aihua2; Han, Charles C.3 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2013 |
| 卷号 | 3期号:30页码:12398-12402 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c3ra22835e |
| 英文摘要 | In this work, electrospun poly(lactide-co-glycolide) (PLGA) fibrous membranes were functionalized with radionuclides by surface modification. After the introduction of chitosan and bifunctional ligands (DTPA) on soft hydrolyzed PLGA nanofibrous membranes, more than 80% of the radionuclides (Y-90) in aqueous solutions were attached as labels to the target nanofibers. To get a high chelating efficiency without changing the physical properties of the membranes, the hydrolysis conditions, the reactive media for the introduction of DTPA, and the chelating time were thoroughly investigated. These radionuclide labelled PLGA fibrous membranes have similar mechanical properties as human tissues. Y-90 on PLGA nanofibers shows a desirable stability of more than four half-lives. |
| 语种 | 英语 |
| WOS记录号 | WOS:000321623200060 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/54595]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | He, Aihua |
| 作者单位 | 1.Nanchang Univ, Sch Mat Sci & Engn, Nanchang 330047, Peoples R China 2.Qingdao Univ Sci & Technol, Sch Polymer Sci & Engn, Minist Educ, Key Lab Rubber Plast, Qingdao 266042, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nie, Huarong,He, Aihua,Han, Charles C.. Immobilization of radionuclides on poly(lactide-co-glycolide) nanofibrous membranes[J]. RSC ADVANCES,2013,3(30):12398-12402. |
| APA | Nie, Huarong,He, Aihua,&Han, Charles C..(2013).Immobilization of radionuclides on poly(lactide-co-glycolide) nanofibrous membranes.RSC ADVANCES,3(30),12398-12402. |
| MLA | Nie, Huarong,et al."Immobilization of radionuclides on poly(lactide-co-glycolide) nanofibrous membranes".RSC ADVANCES 3.30(2013):12398-12402. |
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来源：化学研究所
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