c(RGDfK) decorated micellar drug delivery system for intravesical instilled chemotherapy of superficial bladder cancer
文献类型：期刊论文
| 作者 | Zhou, Danhua1,3; Zhang, Guan2; Gan, Zhihua1 |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2013-08-10 |
| 卷号 | 169期号:3页码:204-210 |
| 关键词 | Superficial Bladder Cancer Targeting Drug Delivery Amphiphilic Block Copolymer Micelles c(Rgdfk) Peptide Conjugation |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2013.01.025 |
| 英文摘要 | The aim of this work was to develop a targeted drug delivery system with potentials for intravesical instilled chemotherapy of superficial bladder cancer. The amphiphilic diblock copolymer poly(epsilon-caprolactone)-b-poly(ethylene oxide) (PCL-b-PEO) was first conjugated with the cyclic (Arginine-Glycine-Aspartic acid-D-Phenylalanine-Lysine) (c(RGDfK)) and fluorescein isothiocyannate (FITC) via the functional terminal groups of hydrophilic block, and then assembled into micelles. The interaction between micelles and various model cells was well studied by means of confocal laser scanning microscopy and flow cytometry. The c(RGDfK) on the surface of the micelle was confirmed by H-1 NMR analysis and cell affinity with human glioblastoma-astrocytoma cells (U87MG). The cell viability of bladder cancer cells (T-24 cells) after incubation with doxorubicin (DOX) loaded polymeric micelles was evaluated by in vitro cytotoxicity assay. The results revealed that c(RGDfK) modified micelles showed strong affinity to T-24 cells and strong inhibitory effect on the proliferation of T-24 cells when doxorubicin drug was loaded, indicating the high affinity of c(RGDfK) to bladder cancer cells. The c(RGDfK) modified micelles assembled from PCL-b-PEO diblock copolymers developed in this study are of great potentials as nano-scaled drug delivery system for intravesical instilled chemotherapy of superficial bladder cancer. (C) 2013 Elsevier B. V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000320650500007 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/54649]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, Guan |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China 2.China Japan Friendship Hosp, Dept Urol, Beijing 100029, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Danhua,Zhang, Guan,Gan, Zhihua. c(RGDfK) decorated micellar drug delivery system for intravesical instilled chemotherapy of superficial bladder cancer[J]. JOURNAL OF CONTROLLED RELEASE,2013,169(3):204-210. |
| APA | Zhou, Danhua,Zhang, Guan,&Gan, Zhihua.(2013).c(RGDfK) decorated micellar drug delivery system for intravesical instilled chemotherapy of superficial bladder cancer.JOURNAL OF CONTROLLED RELEASE,169(3),204-210. |
| MLA | Zhou, Danhua,et al."c(RGDfK) decorated micellar drug delivery system for intravesical instilled chemotherapy of superficial bladder cancer".JOURNAL OF CONTROLLED RELEASE 169.3(2013):204-210. |
入库方式： OAI收割
来源：化学研究所
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