Mechanism and Cellular Kinetic Studies of the Enhancement of Antioxidant Activity by Using Surface-Functionalized Gold Nanoparticles
文献类型：期刊论文
| 作者 | Du, Libo1; Suo, Siqingaowa1; Wang, Guangqing1; Jia, Hongying1; Liu, Ke Jian2; Zhao, Baolu3; Liu, Yang1 |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2013 |
| 卷号 | 19期号:4页码:1281-1287 |
| 关键词 | Antioxidants Cytotoxicity Gold Kinetics Nanoparticles Self-assembly |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.201203506 |
| 英文摘要 | The enhanced antioxidant activity of surface-functionalized gold nanoparticles (AuNPs) synthesized by self-assembly has attracted great attention, but little is known about the mechanism behind the enhanced activity. To address this challenge, the antioxidant activity of Au@PEG3SA (i.e., surface-functionalization of spherical AuNPs with the antioxidant salvianic acid A) was used as an example to illustrate the mechanism of the enhanced activity. Evaluation of the antioxidant activity was performed in a radical-scavenging reaction between Au@PEG3SA and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. As expected, the rate constant for the reaction of Au@PEG3SA with DPPH was about nine times greater than that for the salvianic acid A monomer. A comparative analysis of the spectral characteristics of Au@PEG3SA and the salvianic acid A monomer further imply that the enhancement of the antioxidative reaction kinetics may be ascribed to the variation in the transition state for the DPPH-radical scavenging reaction through pp stacking interactions between and among adjacent groups on the surface of Au@PEG3SA. On the other hand, the kinetic enhancement of Au@PEG3SA on reactive-oxygen-species (ROS) scavenging can be observed in living cells and in vivo, which possibly provides new insight for the bioapplication of self-assembly of surface-functionalized AuNPs. |
| 语种 | 英语 |
| WOS记录号 | WOS:000313721500018 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/54859]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Ke Jian |
| 作者单位 | 1.Chinese Acad Sci, Ctr Mol Sci, State Key Lab Struct Chem Unstable Species, Inst Chem, Beijing 100190, Peoples R China 2.Univ New Mexico, Coll Pharm, Albuquerque, NM 87131 USA 3.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Libo,Suo, Siqingaowa,Wang, Guangqing,et al. Mechanism and Cellular Kinetic Studies of the Enhancement of Antioxidant Activity by Using Surface-Functionalized Gold Nanoparticles[J]. CHEMISTRY-A EUROPEAN JOURNAL,2013,19(4):1281-1287. |
| APA | Du, Libo.,Suo, Siqingaowa.,Wang, Guangqing.,Jia, Hongying.,Liu, Ke Jian.,...&Liu, Yang.(2013).Mechanism and Cellular Kinetic Studies of the Enhancement of Antioxidant Activity by Using Surface-Functionalized Gold Nanoparticles.CHEMISTRY-A EUROPEAN JOURNAL,19(4),1281-1287. |
| MLA | Du, Libo,et al."Mechanism and Cellular Kinetic Studies of the Enhancement of Antioxidant Activity by Using Surface-Functionalized Gold Nanoparticles".CHEMISTRY-A EUROPEAN JOURNAL 19.4(2013):1281-1287. |
入库方式： OAI收割
来源：化学研究所
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