Conjugated Polyelectrolyte Materials for Promoting Progenitor Cell Growth Without Serum
文献类型：期刊论文
| 作者 | Yang, Gaomai; Liu, Libing; Lv, Fengting; Wang, Shu |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2013-04-23 |
| 卷号 | 3 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep01702 |
| 英文摘要 | The discovery of new active biomaterials for promoting progenitor cell growth and differentiation in serum-free medium is still proving more challenging for the clinical treatments of degenerative diseases. In this work, a conjugated polyelectrolyte, polythiophene derivative (PMNT), was discovered to significantly drive the cell cycle progression from G(1) to S and G(2) phases and thus efficiently promote the cell growth without the need of serum. Furthermore, the fluorescent characteristic of PMNT makes it simultaneously able to trace its cellular uptake and localization by cell imaging. cDNA microarray study shows that PMNT can greatly regulate genes related to cell growth or differentiation. To the best of our knowledge, this is the first example of cell growth or differentiation promotion by polyelectrolyte material without the need of serum, thereby providing an important demonstration of degenerative biomaterial discovery through polymer design. |
| 语种 | 英语 |
| WOS记录号 | WOS:000317892500005 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/54861]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Shu |
| 作者单位 | Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Gaomai,Liu, Libing,Lv, Fengting,et al. Conjugated Polyelectrolyte Materials for Promoting Progenitor Cell Growth Without Serum[J]. SCIENTIFIC REPORTS,2013,3. |
| APA | Yang, Gaomai,Liu, Libing,Lv, Fengting,&Wang, Shu.(2013).Conjugated Polyelectrolyte Materials for Promoting Progenitor Cell Growth Without Serum.SCIENTIFIC REPORTS,3. |
| MLA | Yang, Gaomai,et al."Conjugated Polyelectrolyte Materials for Promoting Progenitor Cell Growth Without Serum".SCIENTIFIC REPORTS 3(2013). |
入库方式： OAI收割
来源：化学研究所
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