Transferrin Modified Graphene Oxide for Glioma-Targeted Drug Delivery: In Vitro and in Vivo Evaluations
文献类型：期刊论文
| 作者 | Liu, Guodong1; Shen, He2,6,7; Mao, Jinning3; Zhang, Liming2; Jiang, Zhen4; Sun, Tao5; Lan, Qing1; Zhang, Zhijun2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2013-08-14 |
| 卷号 | 5期号:15页码:6909-6914 |
| ISSN号 | 1944-8244 |
| 关键词 | Graphene Oxide Transferrin Doxorubicin Glioma Chemotherapy In Vivo |
| DOI | 10.1021/am402128s |
| 英文摘要 | Transferrin (Tf), an iron-transporting serum glycoprotein that binds to receptors overexpressed at the surface of glioma cells, was chosen as the ligand to develop Tf-conjugated PEGylated nanoscaled graphene oxide (GO) for loading and glioma targeting delivery of anticancer drug doxorubicin (Dox) (Tf-PEG-GO-Dox). Tf-GO with lateral dimensions of 100-400 nm exhibited a Dox loading ratio up to 115.4%. Compared with Dox-loaded PEGylated GO (PEG-GO-Dox) and free Dox, Tf-PEG-GO-Dox displayed greater intracellular delivery efficiency and stronger cytotoxicity against C6 glioma cells. A competition test showed that Tf was essential to glioma targeting in vitro. The HPLC assay for Dox concentration in tumor tissue and contrapart tissue of the brain demonstrated that Tf-PEG-GO-Dox could deliver more Dox into tumor in vivo. The life span of tumor bearing rats after the administration of Tf-PEG-GO-Dox was extended significantly compared to the rats treated with saline, Dox, and PEG-GO-Dox In conclusion, we developed Tf-PEG-GO-Dox which exhibited significantly improved therapeutic efficacy for glioma both in vitro and in vivo. |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000323241100021 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/54913]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Lan, Qing |
| 作者单位 | 1.Soochow Univ, Affiliated Hosp 2, Dept Neurosurg, Suzhou 215004, Peoples R China 2.Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Div Nanobiomed, Suzhou Key Lab Nanobiomed, Suzhou 215123, Peoples R China 3.Soochow Univ, Affiliated Hosp 2, Cardiovasc Dept, Suzhou 215004, Peoples R China 4.Soochow Univ, Affiliated Hosp 2, Radiol Dept, Suzhou 215004, Peoples R China 5.Xian Jiaotong Liverpool Univ, Dept Biol Sci, Suzhou 215123, Peoples R China 6.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 7.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Guodong,Shen, He,Mao, Jinning,et al. Transferrin Modified Graphene Oxide for Glioma-Targeted Drug Delivery: In Vitro and in Vivo Evaluations[J]. ACS APPLIED MATERIALS & INTERFACES,2013,5(15):6909-6914. |
| APA | Liu, Guodong.,Shen, He.,Mao, Jinning.,Zhang, Liming.,Jiang, Zhen.,...&Zhang, Zhijun.(2013).Transferrin Modified Graphene Oxide for Glioma-Targeted Drug Delivery: In Vitro and in Vivo Evaluations.ACS APPLIED MATERIALS & INTERFACES,5(15),6909-6914. |
| MLA | Liu, Guodong,et al."Transferrin Modified Graphene Oxide for Glioma-Targeted Drug Delivery: In Vitro and in Vivo Evaluations".ACS APPLIED MATERIALS & INTERFACES 5.15(2013):6909-6914. |
入库方式： OAI收割
来源：化学研究所
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