Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid)
文献类型：期刊论文
| 作者 | Zhao, H; Li, JR; Jiang, L |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2004-07-16 |
| 卷号 | 320期号:1页码:95-99 |
| 关键词 | Inhibition Poly(Acrylic Acid) Tat Peptide Tar Rna Quartz Crystal Microbalance |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2004.05.148 |
| 英文摘要 | HIV-1 is regulated at the transcriptional level by the interaction of Tat protein with the transactivation responsive region (TAR) RNA, a 59-base stem-loop structure located at the 5'-end of all nascent HIV-1 transcripts. Here, by targeting the Tat peptide, we found that negatively charged poly(acrylic acid) (PAA) had high affinity with Tat peptide and could inhibit the interaction of TAR with Tat. Therefore, PAA could block HIV replication by binding to Tat not to TAR RNA, providing a new thinking for the design of novel anti-HIV drugs. (C) 2004 Elsevier Inc. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000222494500015 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/55093]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jiang, L |
| 作者单位 | Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, H,Li, JR,Jiang, L. Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid)[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,320(1):95-99. |
| APA | Zhao, H,Li, JR,&Jiang, L.(2004).Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid).BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,320(1),95-99. |
| MLA | Zhao, H,et al."Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid)".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 320.1(2004):95-99. |
入库方式： OAI收割
来源：化学研究所
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