Thermodynamics and structures of amide phospholipid monolayers
文献类型：期刊论文
| 作者 | Zhai, XH; Brezesinski, G; Mohwald, H; Li, JB |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY B
 |
| 出版日期 | 2004-09-02 |
| 卷号 | 108期号:35页码:13475-13480 |
| ISSN号 | 1520-6106 |
| DOI | 10.1021/jp047260d |
| 英文摘要 | Monolayers of newly synthesized amide phospholipids, 1-O-hexadecyl-2-N-palmitoyl-2-amino-2-deoxy-snglycero-3-phosphocholine (L-ether-amide-PC) and 1-palmitoyl-2-N-palmitoyl-2-amino-2-deoxy-sn-glycero3-phosphocholine (L-ester-amide-PC) were investigated at the air/subphase interface by Brewster angle microscopy combined with a conventional LB trough and Grazing incidence X-ray diffraction (GIXD). Both systems investigated exhibit two-dimensional domains with characteristic shape in the coexistence region between liquid-expanded (LE) and liquid-condensed (LC) phases. Especially L-ether-amide-PC shows highly chiral domains depending on temperature. The largest chiral domains (400 mum) growing in a clockwise direction are obtained at 25degreesC. Such large domains have rarely been observed for phospholipids before. Thermodynamic data derived from pi-A isotherms provide information about critical temperature (T-c) and phase transition enthalpy (DeltaH) for both amide phospholipids. The amide group leads to pronounced differences in the thermodynamic parameters compared with DPPC. The two-dimensional structures of the monolayers were investigated by GIXD. The results show that both amide phospholipids exhibit chiral in-plane structures. In the case Of L-ether-amide-PC, the tilt angle of the aliphatic chains decreases only slightly with increasing pressure. On the contrary, the tilt angle of the aliphatic chains Of L-ester-amide-PC shows strong dependence on surface pressure similar to DPPC. Possible hydrogen bonds involving the amide group seem to enhance the chiral interaction and play therefore a key role in the formation of extremely large chiral domains. The affects of substitution in the sn-1 position on structure formation are discussed in detail. |
| 语种 | 英语 |
| WOS记录号 | WOS:000223600800055 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/55317]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Brezesinski, G |
| 作者单位 | 1.Chinese Acad Sci, Int Joint Lab, Key Lab Colloid & Interface Sci, Ctr Mol Sci,Inst Chem, Beijing 100080, Peoples R China 2.Max Planck Inst Colloids & Interfaces, D-14476 Potsdam, Germany |
| 推荐引用方式 GB/T 7714 | Zhai, XH,Brezesinski, G,Mohwald, H,et al. Thermodynamics and structures of amide phospholipid monolayers[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2004,108(35):13475-13480. |
| APA | Zhai, XH,Brezesinski, G,Mohwald, H,&Li, JB.(2004).Thermodynamics and structures of amide phospholipid monolayers.JOURNAL OF PHYSICAL CHEMISTRY B,108(35),13475-13480. |
| MLA | Zhai, XH,et al."Thermodynamics and structures of amide phospholipid monolayers".JOURNAL OF PHYSICAL CHEMISTRY B 108.35(2004):13475-13480. |
入库方式： OAI收割
来源：化学研究所
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