Polyamidoamine dendrimers inhibit binding of Tat peptide to TAR RNA
文献类型：期刊论文
| 作者 | Zhao, H; Li, JR; Xi, F; Jiang, L |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2004-04-09 |
| 卷号 | 563期号:1-3页码:241-245 |
| 关键词 | Trans-acting Responsive Element Rna Tat Peptide Quartz Crystal Microbalance Polyamidoamine Dendrimer |
| ISSN号 | 0014-5793 |
| DOI | 10.1016/S0014-5793(04)00284-4 |
| 英文摘要 | The binding of polyamidoamine (PAMAM) dendrimer or Tat peptide to trans-acting responsive element (TAR) RNA has been studied using microgravimetric quartz crystal microbalance (QCM). Experimental results showed that PAMAM dendrimer could form complexes with TAR RNA. Especially, PAMAM dendrimer could disrupt the interaction of Tat peptide with TAR RNA, which is essential for HIV-1 virus replication, suggesting that QCM is a powerful tool for studying the binding processes of Tat peptide-TAR RNA and drug-TAR RNA and has great significance for the design of new drugs. An equation to measure the binding ability between TAR RNA and other species has been proposed. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000220773200045 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/55537]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jiang, L |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, H,Li, JR,Xi, F,et al. Polyamidoamine dendrimers inhibit binding of Tat peptide to TAR RNA[J]. FEBS LETTERS,2004,563(1-3):241-245. |
| APA | Zhao, H,Li, JR,Xi, F,&Jiang, L.(2004).Polyamidoamine dendrimers inhibit binding of Tat peptide to TAR RNA.FEBS LETTERS,563(1-3),241-245. |
| MLA | Zhao, H,et al."Polyamidoamine dendrimers inhibit binding of Tat peptide to TAR RNA".FEBS LETTERS 563.1-3(2004):241-245. |
入库方式： OAI收割
来源：化学研究所
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