Acetylcholine release in the hippocampus during the operant conditioned reflex and the footshock stimulus in rats
文献类型：期刊论文
| 作者 | Dong, Y; Mao, JJ; Shangguan, DH; Zhao, R; Liu, GQ |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2004-10-14 |
| 卷号 | 369期号:2页码:121-125 |
| 关键词 | Training Microdialysis Footshock Rat |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2004.07.048 |
| 英文摘要 | The activity of the septo-hippocampal cholinergic pathway was investigated by measuring changes in the extracellular acetylcholine (ACh) levels in the hippocampus, by means of microdialysis, during the operant conditioned reflex and the repeated footshock stimulus. Microdialysis samplings were conducted in a Skinner box where lights were delivered as conditioned stimuli (CS) paired with footshocks as unconditioned stimuli (US). Two groups of rats were used. Extracellular ACh and choline (Ch) in samples collected at 6 min intervals were assessed by high-performance liquid chromatography with electrochemical detection. The elevation of hippocampus ACh was observed in the two experimental groups. The increase in ACh during aversive stimulus (footshock) was significantly larger and was probably related to the number of footshocks. There might be moderate increase in the hippocampal ACh release during the retrieval of information. The concentration of choline showed no significant fluctuation in the two groups during the whole process. This experiment explored in more detail hippocampal cholinergic activity in relation to the two different procedures. (C) 2004 Elsevier Ireland Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000224438100007 |
| 出版者 | ELSEVIER SCI IRELAND LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/55565]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, R |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Y,Mao, JJ,Shangguan, DH,et al. Acetylcholine release in the hippocampus during the operant conditioned reflex and the footshock stimulus in rats[J]. NEUROSCIENCE LETTERS,2004,369(2):121-125. |
| APA | Dong, Y,Mao, JJ,Shangguan, DH,Zhao, R,&Liu, GQ.(2004).Acetylcholine release in the hippocampus during the operant conditioned reflex and the footshock stimulus in rats.NEUROSCIENCE LETTERS,369(2),121-125. |
| MLA | Dong, Y,et al."Acetylcholine release in the hippocampus during the operant conditioned reflex and the footshock stimulus in rats".NEUROSCIENCE LETTERS 369.2(2004):121-125. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。