Recent advances in triplex deoxyribonucleic acid research
文献类型：期刊论文
| 作者 | Ling, LS; Wang, J; Fang, XH; Chen, DM; Bai, CL |
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2004-09-01 |
| 卷号 | 32期号:9页码:1252-1255 |
| 关键词 | Triplex Deoxyribonucleic Aicd Duplex Deoxyribonucleic Aicd Review |
| ISSN号 | 0253-3820 |
| 英文摘要 | Recent advances in the study of triplex deoxyribonucleic acid (DNA) are reviewed from three aspects: Firstly, triplex DNA stability study. The stability of triplex DNA is not only determined by the oligonucleotides base sequence, but also dependent on several other factors, such as pH, concentration of cations, DNA intercalative agents and copolymer etc. Secondly, triplex DNA application. The formation of triple helix DNA offers-a powerful tool for genetic manipulation and genetic therapy. The triplex DNA can be used to inhibit DNA transcription and replication, generate site-specific mutations, cleave DNA, and induce homologous recombination. Thirdly, triplex DNA detection. Many analytical methods have been developed for the sensitive detection of triplex DNA, such as UV-visible absorption spectrum, fluorescence analysis, atomic force microscopy and electron paramagnetic resonance spectra etc. In the end, the potential development of triplex DNA is addressed. |
| 语种 | 英语 |
| WOS记录号 | WOS:000224542700032 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/55643]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Bai, CL |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China 2.Harvard Univ, Rowland Inst, Cambridge, MA 02142 USA |
| 推荐引用方式 GB/T 7714 | Ling, LS,Wang, J,Fang, XH,et al. Recent advances in triplex deoxyribonucleic acid research[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2004,32(9):1252-1255. |
| APA | Ling, LS,Wang, J,Fang, XH,Chen, DM,&Bai, CL.(2004).Recent advances in triplex deoxyribonucleic acid research.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,32(9),1252-1255. |
| MLA | Ling, LS,et al."Recent advances in triplex deoxyribonucleic acid research".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 32.9(2004):1252-1255. |
入库方式： OAI收割
来源：化学研究所
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