Analysis of protein-protein interface
文献类型：期刊论文
| 作者 | Gao, Y; Lai, LH |
| 刊名 | ACTA PHYSICO-CHIMICA SINICA
 |
| 出版日期 | 2004-07-01 |
| 卷号 | 20期号:7页码:676-679 |
| 关键词 | Protein-protein Interaction Pp_site Procedure Interface Classification |
| ISSN号 | 1000-6818 |
| DOI | 10.3866/PKU.WHXB20040702 |
| 英文摘要 | Analysis of protein-protein interface is crucial to understand protein interactions and to develop drugs targeting protein complexes. PP_SITE is a method developed by the author's group to deduce hydrogen bond and hydrophobic properties for protein-protein interface. We have used PP_SITE to perform statistical analysis on protein-protein interfaces. A two-chain non-redundant interface dataset from PDB was constructed and used in the study. According to the hydrophobicity and hydrogen bond characteristics, criteria were selected to differentiate protein interfaces into distinct groups. The size of interface, the proportion of hydrophobic and hydrophilic property and the extent of concentration in hydrophobicity were found to be important for interface classification. |
| 语种 | 英语 |
| WOS记录号 | WOS:000222794400002 |
| 出版者 | PEKING UNIV PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/55791]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Lai, LH |
| 作者单位 | Peking Univ, Coll Chem & Mol Engn, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Y,Lai, LH. Analysis of protein-protein interface[J]. ACTA PHYSICO-CHIMICA SINICA,2004,20(7):676-679. |
| APA | Gao, Y,&Lai, LH.(2004).Analysis of protein-protein interface.ACTA PHYSICO-CHIMICA SINICA,20(7),676-679. |
| MLA | Gao, Y,et al."Analysis of protein-protein interface".ACTA PHYSICO-CHIMICA SINICA 20.7(2004):676-679. |
入库方式： OAI收割
来源：化学研究所
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