Remarkably diastereoselective synthesis of a chiral biphenyl diphosphine ligand and its application in asymmetric hydrogenation
文献类型：期刊论文
| 作者 | Qiu, LQ; Wu, J; Chan, SS; Au-Yeung, TTL; Ji, JX; Guo, RW; Pai, CC; Zhou, ZY; Li, XS; Fan, QH |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2004-04-20 |
| 卷号 | 101期号:16页码:5815-5820 |
| ISSN号 | 0027-8424 |
| DOI | 10.1073/pnas.0307774101 |
| 英文摘要 | Essentially complete atropdiastereoselectivity was realized in the preparation of biaryl diphosphine dioxide by asymmetric intramolecular Ullmann coupling and oxidative coupling with central-to-axial chirality transfer. A bridged C-2-symmetric biphenyl phosphine ligand possessing additional chiral centers on the linking unit of the biphenyl groups was synthesized. No resolution step was required for the preparation of the enantiomerically pure chiral ligand. These findings offer a general and practical tool for the development of previously uninvestigated atropdiastereomeric biaryl phosphine ligands. The diphosphine ligand was found to be highly effective in the asymmetric hydrogenation of alpha- and beta-ketoesters, 2-(6'-methoxy-2'-naphthyl)propenoic acid, beta-(acylamino)acrylates, and enol acetates. |
| 语种 | 英语 |
| WOS记录号 | WOS:000220978000025 |
| 出版者 | NATL ACAD SCIENCES |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/55793]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chan, ASC |
| 作者单位 | 1.Hong Kong Polytech Univ, Open Lab Chirotechnol, Inst Mol Technol Drug Discovery & Synth, Kowloon, Hong Kong, Peoples R China 2.Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China 3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, LQ,Wu, J,Chan, SS,et al. Remarkably diastereoselective synthesis of a chiral biphenyl diphosphine ligand and its application in asymmetric hydrogenation[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2004,101(16):5815-5820. |
| APA | Qiu, LQ.,Wu, J.,Chan, SS.,Au-Yeung, TTL.,Ji, JX.,...&Chan, ASC.(2004).Remarkably diastereoselective synthesis of a chiral biphenyl diphosphine ligand and its application in asymmetric hydrogenation.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,101(16),5815-5820. |
| MLA | Qiu, LQ,et al."Remarkably diastereoselective synthesis of a chiral biphenyl diphosphine ligand and its application in asymmetric hydrogenation".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101.16(2004):5815-5820. |
入库方式： OAI收割
来源：化学研究所
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