Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate
文献类型：期刊论文
| 作者 | Zhang, XF; Li, YX; Chen, XS; Wang, XH; Xu, XY; Liang, QZ; Hu, JL; Jing, XB |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2005-05-01 |
| 卷号 | 26期号:14页码:2121-2128 |
| 关键词 | Paclitaxel Prodrug Ring-opening Polymerization Diglycolic Anhydride |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2004.06.024 |
| 英文摘要 | A paclitaxel/MPEG-PLA block copolymer conjugate was prepared in three steps: (1) hydroxyl-terminated diblock copolymer of monomethoxy-poly(ethylene glycol)-b-poly(lactide) (MPEG-PLA) was synthesized by ring-opening polymerization of L-lactide using MPEG as a maroinitiator, (2) it was converted to carboxyl-terminated MPEG-PLA by reacting with mono-i-butyl ester of diglycolic acid and subsequent deprotecting the t-butyl group with TFA; (3) the latter was reacted with paclitaxel in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine. Structures of the polymers synthesized were confirmed by H-1 NMR, and their molecular weights were determined by gel permeation chromatography. The antitumor activity of the conjugate against human liver cancer H7402 cells was evaluated by MTT method. The results showed that paclitaxel can be released from the conjugate without losing cytotoxicity. (C) 2004 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000226663800054 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/55943]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, XB |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Grad Sch, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.NE Normal Univ, Inst Genet & Cytol, Changchun 130024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, XF,Li, YX,Chen, XS,et al. Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate[J]. BIOMATERIALS,2005,26(14):2121-2128. |
| APA | Zhang, XF.,Li, YX.,Chen, XS.,Wang, XH.,Xu, XY.,...&Jing, XB.(2005).Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate.BIOMATERIALS,26(14),2121-2128. |
| MLA | Zhang, XF,et al."Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate".BIOMATERIALS 26.14(2005):2121-2128. |
入库方式： OAI收割
来源：化学研究所
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