Preparation and evaluation of poly(L-lactide-co-glycolide) (PLGA) microbubbles as a contrast agent for myocardial contrast echocardiography
文献类型：期刊论文
| 作者 | Cui, WJ; Bei, JZ; Wang, SG; Zhi, G; Zhao, YY; Zhou, XS; Zhang, HW; Xu, Y |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
 |
| 出版日期 | 2005-04-01 |
| 卷号 | 73B期号:1页码:171-178 |
| 关键词 | Microspheres Contrast Agent Biodegradation In Vivo Myocardium Opacification |
| ISSN号 | 1552-4973 |
| DOI | 10.1002/jbm.b.30189 |
| 英文摘要 | A kind of absorbable PLGA microbubble-based contrast agent (PLGA microspheres with porous or hollow inner structure) was fabricated by an improved double emulsion-solvent evaporation method. The contrast efficiency was evaluated and proved both in vitro and in vivo. By adjusting the polymer concentration and volume of the inner aqueous phase during the fabrication of microbubbles, the inner structure of the microbubbles could be controlled. Both air-filled and perfluoropropane-filled microbubbles can opacify the left ventricle. However, when compared with air-filled microbubbles, perfluoropropane-filled microbubbles can produce significantly longer enhancement in left ventricle in the dog model due to the lower diffusivity and lower solubility of perfluoropropane in blood. A suspension of perfluoropropane-filled PLGA microbubbles (1.8 mu m average microbubbles size, 2 x 10(8) microbubbles/mL concentration) has successfully and safely achieved myocardial opacification in closed-chest dogs. A perfusion defect was observed in both of the two dogs with acute myocardial infarction with Power Contrast Imaging (PCI) triggered technology. In the examination of contrast in both ventricular and myocardial opacification, the high mechanical index (MI) was found to have superior contrast sensitivity over the low MI for PLGA-based contrast agents. (c) 2005 Wiley Periodicals, Inc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000228076000023 |
| 出版者 | WILEY-LISS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/56027]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, SG |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China 2.Gen Hosp Peoples Liberat Army, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, WJ,Bei, JZ,Wang, SG,et al. Preparation and evaluation of poly(L-lactide-co-glycolide) (PLGA) microbubbles as a contrast agent for myocardial contrast echocardiography[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2005,73B(1):171-178. |
| APA | Cui, WJ.,Bei, JZ.,Wang, SG.,Zhi, G.,Zhao, YY.,...&Xu, Y.(2005).Preparation and evaluation of poly(L-lactide-co-glycolide) (PLGA) microbubbles as a contrast agent for myocardial contrast echocardiography.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,73B(1),171-178. |
| MLA | Cui, WJ,et al."Preparation and evaluation of poly(L-lactide-co-glycolide) (PLGA) microbubbles as a contrast agent for myocardial contrast echocardiography".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 73B.1(2005):171-178. |
入库方式： OAI收割
来源：化学研究所
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