Preparation and characterization of biodegradable insulin-loaded microspheres
文献类型：期刊论文
| 作者 | Zhang, XF; Hu, JL; Chen, XS; Jing, XB |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2005-03-10 |
| 卷号 | 26期号:3页码:554-557 |
| 关键词 | Biodegradable Polymer Controlled Release Of Drugs Polymer Alloy Insulin |
| ISSN号 | 0251-0790 |
| 英文摘要 | Insulin-loaded microspheres were prepared by solid-in-oil-in-water (S/O/W) technique with a polymer alloy of poly (lactic acid-co-glycolic acid) (PLGA) and monomethoxy polyethylene glycol-b-polylactic acid (MPEG-PLA) as the carrier material. It was demonstrated that the microspheres prepared by the S/O/W technique contain more insulin than those prepared by water-in-oil-in-water(W/O/W). They had a spherical shape. Their mean size was in the range of 1-3 mu m. Their cross-section had a core-shell structure and the insulin located in the core of the capsule as a crystal solid. The shell itself was layered due to the phase-separation of the polymer alloy during the course of solvent evaporation. The in vitro release behavior of the insulin mirospheres prepared by S/O/W and by W/O/W were compared. It was found that less initial burst release of insulin from the mirospheres prepared by S/O/W was observed than the other. This improvement in initial burst release was dependent on the ratio of the two components of the polymer alloy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000228021800037 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/56329]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, XB |
| 作者单位 | Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, XF,Hu, JL,Chen, XS,et al. Preparation and characterization of biodegradable insulin-loaded microspheres[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2005,26(3):554-557. |
| APA | Zhang, XF,Hu, JL,Chen, XS,&Jing, XB.(2005).Preparation and characterization of biodegradable insulin-loaded microspheres.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,26(3),554-557. |
| MLA | Zhang, XF,et al."Preparation and characterization of biodegradable insulin-loaded microspheres".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 26.3(2005):554-557. |
入库方式： OAI收割
来源：化学研究所
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