Preparation and characterization of biodegradable insulin-loaded microspheres
文献类型:期刊论文
作者 | Zhang, XF; Hu, JL; Chen, XS; Jing, XB |
刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
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出版日期 | 2005-03-10 |
卷号 | 26期号:3页码:554-557 |
关键词 | Biodegradable Polymer Controlled Release Of Drugs Polymer Alloy Insulin |
ISSN号 | 0251-0790 |
英文摘要 | Insulin-loaded microspheres were prepared by solid-in-oil-in-water (S/O/W) technique with a polymer alloy of poly (lactic acid-co-glycolic acid) (PLGA) and monomethoxy polyethylene glycol-b-polylactic acid (MPEG-PLA) as the carrier material. It was demonstrated that the microspheres prepared by the S/O/W technique contain more insulin than those prepared by water-in-oil-in-water(W/O/W). They had a spherical shape. Their mean size was in the range of 1-3 mu m. Their cross-section had a core-shell structure and the insulin located in the core of the capsule as a crystal solid. The shell itself was layered due to the phase-separation of the polymer alloy during the course of solvent evaporation. The in vitro release behavior of the insulin mirospheres prepared by S/O/W and by W/O/W were compared. It was found that less initial burst release of insulin from the mirospheres prepared by S/O/W was observed than the other. This improvement in initial burst release was dependent on the ratio of the two components of the polymer alloy. |
语种 | 英语 |
WOS记录号 | WOS:000228021800037 |
出版者 | HIGHER EDUCATION PRESS |
源URL | [http://ir.iccas.ac.cn/handle/121111/56329] ![]() |
专题 | 中国科学院化学研究所 |
通讯作者 | Jing, XB |
作者单位 | Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, XF,Hu, JL,Chen, XS,et al. Preparation and characterization of biodegradable insulin-loaded microspheres[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2005,26(3):554-557. |
APA | Zhang, XF,Hu, JL,Chen, XS,&Jing, XB.(2005).Preparation and characterization of biodegradable insulin-loaded microspheres.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,26(3),554-557. |
MLA | Zhang, XF,et al."Preparation and characterization of biodegradable insulin-loaded microspheres".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 26.3(2005):554-557. |
入库方式: OAI收割
来源:化学研究所
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