Synthesis and characterization of novel biodegradable block copolymer poly(ethylene glycol)-block-poly (L-lactide-co-2-methyl-2-carboxyl-propylene carbonate)
文献类型：期刊论文
| 作者 | Guan, HL; Xie, ZG; Zhang, PB; Wang, X; Chen, XS; Wang, XH; Jing, XB |
| 刊名 | JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
 |
| 出版日期 | 2005-10-15 |
| 卷号 | 43期号:20页码:4771-4780 |
| 关键词 | Biodegradable Carbonate Functionalization Of Polymers Polylactide Ring-opening Polymerization |
| ISSN号 | 0887-624X |
| DOI | 10.1002/pola.20942 |
| 英文摘要 | An amphiphilic block copolymer, poly(ethylene glycol)-block-poly(L-lactideco-2-methyl-2-benzoxycarbonyl-propylene carbonate) [PEG-b-P(LA-co-MBC)], was synthesized in bulk by the ring-opening polymerization Of L-lactide with 2-methyl-2-benzoxycarbonyl-propylene carbonate (MBC) in the presence of poly(ethylene glycol) as a macroinitiator with diethyl zinc as a catalyst. The subsequent catalytic hydrogenation of PEG-b-P(LA-co-MBC) with palladium hydroxide on activated charcoal (20%) as a catalyst was carried out to obtain the corresponding linear copolymer poly(ethyleneglycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylenecarbonate) [PEG-b-P(LA-co-MCC)] with pendant carboxyl groups. DSC analysis indicated that the glass-transition temperature (T-g) of PEG-b-MA-co-MBQ decreased with increasing MBC content in the copolymer, and T-g of PEG-b-P(LA-co-MCC) was higher than that of the corresponding PEG-b-P(LA-co-MBC). The in vitro degradation rate of PEG-b-P(LA-co-MCC) in the presence of proteinase K was faster than that of PEG-b-P(LA-co-MBC), and the cytotoxicity of PEG-b-P(LA-co-MCC) to chondrocytes from human fetal arthrosis was lower than that of poly (L-lactide). (c) 2005 Wiley Periodicals, Inc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000232407200009 |
| 出版者 | JOHN WILEY & SONS INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/56425]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, XB |
| 作者单位 | 1.Acad Sinica, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, HL,Xie, ZG,Zhang, PB,et al. Synthesis and characterization of novel biodegradable block copolymer poly(ethylene glycol)-block-poly (L-lactide-co-2-methyl-2-carboxyl-propylene carbonate)[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2005,43(20):4771-4780. |
| APA | Guan, HL.,Xie, ZG.,Zhang, PB.,Wang, X.,Chen, XS.,...&Jing, XB.(2005).Synthesis and characterization of novel biodegradable block copolymer poly(ethylene glycol)-block-poly (L-lactide-co-2-methyl-2-carboxyl-propylene carbonate).JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,43(20),4771-4780. |
| MLA | Guan, HL,et al."Synthesis and characterization of novel biodegradable block copolymer poly(ethylene glycol)-block-poly (L-lactide-co-2-methyl-2-carboxyl-propylene carbonate)".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 43.20(2005):4771-4780. |
入库方式： OAI收割
来源：化学研究所
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