Study on the interactions and cleavage of Cu(RA)(2)center dot 3H(2)O with DNA
文献类型：期刊论文
| 作者 | Yang, PJ; Sun, K; Su, X; Wang, LF; Song, YM |
| 刊名 | ACTA CHIMICA SINICA
 |
| 出版日期 | 2005-12-14 |
| 卷号 | 63期号:23页码:2153-2157 |
| 关键词 | Cu(Ra)(2)Center Dot 3h(2)o Calf Thymus Dna Cleavage Electrochemistry |
| ISSN号 | 0567-7351 |
| 英文摘要 | The interactions of the Cu(II) complex of all-trans retinoic acid [Cu(RA)(2)center dot 3H(2)O] with DNA have been studied using agarose gel electrophoresis, fluorescence spectroscopy, viscosity measurement and electrochemical methods. The results indicate that the Cu(RA)(2)center dot 3H(2)O can effectively promote the cleavage of plasmid DNA at physiological pH and temperature, and also increase the viscosity of DNA. The emission intensity was quenched as Cu(RA)(2)center dot 3H(2)O was added to the EB-DNA system. The results above suggest that the complex should bind DNA mainly by intercalation, to cause a decrease of anodic peak current in their cyclic voltammograms and exhibit enhanced DNA binding. |
| 语种 | 英语 |
| WOS记录号 | WOS:000233813100010 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/56499]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, PJ |
| 作者单位 | 1.NW Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Peoples R China 2.Chinese Acad Sci, Inst Chem & Phys, State Key Lab Carbonyl Synth & Oxidat, Lanzhou 730000, Peoples R China 3.NW Normal Univ, Coll Life Sci, Lanzhou 730070, Peoples R China 4.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, PJ,Sun, K,Su, X,et al. Study on the interactions and cleavage of Cu(RA)(2)center dot 3H(2)O with DNA[J]. ACTA CHIMICA SINICA,2005,63(23):2153-2157. |
| APA | Yang, PJ,Sun, K,Su, X,Wang, LF,&Song, YM.(2005).Study on the interactions and cleavage of Cu(RA)(2)center dot 3H(2)O with DNA.ACTA CHIMICA SINICA,63(23),2153-2157. |
| MLA | Yang, PJ,et al."Study on the interactions and cleavage of Cu(RA)(2)center dot 3H(2)O with DNA".ACTA CHIMICA SINICA 63.23(2005):2153-2157. |
入库方式： OAI收割
来源：化学研究所
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