Synthesis and characterization of poly(ethylene glycol)-b-poly (L-lactide)-b-poly(L-glutamic acid) triblock copolymer
文献类型：期刊论文
| 作者 | Deng, C; Rong, GZ; Tian, HY; Tang, ZH; Chen, XS; Jing, XB |
| 刊名 | POLYMER
 |
| 出版日期 | 2005-01-26 |
| 卷号 | 46期号:3页码:653-659 |
| 关键词 | Biodegradable Polymer Block Copolymer Ring-opening Polymerization |
| ISSN号 | 0032-3861 |
| DOI | 10.1016/j.polymer.2004.11.100 |
| 英文摘要 | A biodegradable amphiphilic triblock copolymer of poly(ethylene glycol)-b-poly(L-lactide)-b-poly(L-glutamic acid) (PEG-b-PLLA-b-PLGA) was obtained by catalytic hydrogenation of poly(ethylene glycol)-b-poly(L-lactide)-b-poly(gamma-benzyl-L-glutamic acid) (PEG-b-PLLA-b-PBLGA) synthesized by the ring-opening polymerization (ROP) of N-carboxyanhydride of gamma-benzyl-L-glutamate (BLG-NCA) with amino-terminated MPEG-b-PLLA-NH2 as a macroinitiator. MPEG-b-PLLA-NH2 converted from MPEG-b-PLLA-OH first reacted with tert-Butoxycarbonyl-L-phenylalanine (Phe-(BOC)-B-N) and dicyclohexylcarbodiimide (DCC) and then deprotected the tert-butoxycarbonyl group. MPEG-b-PLLA-OH was prepared by ROP of L-lactide with monomethoxy poly(ethylene glycol) in the presence of stannous octoate. The triblock copolymer and its diblock precursors were characterized by H-1 NMR, FTIR, GPC and DSA (drop shape analysis) measurements. The lengths of each block polymers could be tailored by molecular design and the ratios of feeding monomers. The triblock polymer PEG-b-PLLA-b-PLGA containing carboxyl groups showed obviously improved hydrophilic properties and could be a good potential candidate as a drug delivery carrier. (C) 2004 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000226430600006 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/56609]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, XS |
| 作者单位 | Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, C,Rong, GZ,Tian, HY,et al. Synthesis and characterization of poly(ethylene glycol)-b-poly (L-lactide)-b-poly(L-glutamic acid) triblock copolymer[J]. POLYMER,2005,46(3):653-659. |
| APA | Deng, C,Rong, GZ,Tian, HY,Tang, ZH,Chen, XS,&Jing, XB.(2005).Synthesis and characterization of poly(ethylene glycol)-b-poly (L-lactide)-b-poly(L-glutamic acid) triblock copolymer.POLYMER,46(3),653-659. |
| MLA | Deng, C,et al."Synthesis and characterization of poly(ethylene glycol)-b-poly (L-lactide)-b-poly(L-glutamic acid) triblock copolymer".POLYMER 46.3(2005):653-659. |
入库方式： OAI收割
来源：化学研究所
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